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UVSSA antibody [N1N2], N-term

Name: UVSSA antibody [N1N2], N-term
SKU: GTX106751_G10
Availability: BackOrder

GTX106751

ApplicationsImmunoFluorescence, Western Blot, ImmunoCytoChemistry

Product group Antibodies

TargetUVSSA

Overview

Supplier
GeneTex
Product Name
UVSSA antibody [N1N2], N-term
Delivery Days Customer
9
Application Supplier Note
WB: 1:500-1:3000. ICC/IF: 1:100-1:1000. *Optimal dilutions/concentrations should be determined by the researcher.Not tested in other applications.
Applications
ImmunoFluorescence, Western Blot, ImmunoCytoChemistry
Certification
Research Use Only
Clonality
Polyclonal
Concentration
1 mg/ml
Conjugate
Unconjugated
Gene ID57654
Target name
UVSSA
Target description
UV stimulated scaffold protein A
Target synonyms
KIAA1530, UVSS3, UV-stimulated scaffold protein A
Host
Rabbit
Isotype
IgG
Protein IDQ2YD98
Protein Name
UV-stimulated scaffold protein A
Storage Instruction
-20°C or -80°C,2°C to 8°C
UNSPSC
12352203

Liebau RC, Waters C, Ahmed A, et al. Transcription-Coupled Repair of DNA Interstrand Crosslinks by UVSSA. bioRxiv. 2024,:pii: 2023.05.10.538304. doi: 10.1101/2023.05.10.538304.
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Kordon MM, Arron S, Cleaver JE, et al. The UVSSA protein is part of a genome integrity homeostasis network with links to transcription-coupled DNA repair and ATM signaling. Proc Natl Acad Sci U S A. 2022,119(11):e2116254119. doi: 10.1073/pnas.2116254119
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Sato M, Liebau RC, Liu Z, et al. The UVSSA complex alleviates MYC-driven transcription stress. J Cell Biol. 2021,220(2). doi: 10.1083/jcb.201807163
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Higa M, Tanaka K, Saijo M. Inhibition of UVSSA ubiquitination suppresses transcription-coupled nucleotide excision repair deficiency caused by dissociation from USP7. FEBS J. 2018,285(5):965-976. doi: 10.1111/febs.14382
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Higa M, Zhang X, Tanaka K, et al. Stabilization of Ultraviolet (UV)-stimulated Scaffold Protein A by Interaction with Ubiquitin-specific Peptidase 7 Is Essential for Transcription-coupled Nucleotide Excision Repair. J Biol Chem. 2016,291(26):13771-9. doi: 10.1074/jbc.M116.724658
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Zhang X, Horibata K, Saijo M, et al. Mutations in UVSSA cause UV-sensitive syndrome and destabilize ERCC6 in transcription-coupled DNA repair. Nat Genet. 2012,44(5):593-7. doi: 10.1038/ng.2228
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