VAV1 antibody [GT557]

GeneTex

VAV1 antibody [GT557]

9

WB: 1:500-1:3000. ICC/IF: 1:100-1:1000. IHC-P: 1:100-1:1000. *Optimal dilutions/concentrations should be determined by the researcher.Not tested in other applications.

ImmunoFluorescence, Western Blot, ImmunoCytoChemistry, ImmunoHistoChemistry, ImmunoHistoChemistry Paraffin

Research Use Only

Monoclonal

GT557

1 mg/ml

Unconjugated

VAV1

vav guanine nucleotide exchange factor 1

proto-oncogene vav; VAV; vav 1 guanine nucleotide exchange factor; vav 1 oncogene

Mouse

IgG2b

Proto-oncogene vav

The protein encoded by this proto-oncogene is a member of the Dbl family of guanine nucleotide exchange factors (GEF) for the Rho family of GTP binding proteins. The protein is important in hematopoiesis, playing a role in T-cell and B-cell development and activation. This particular GEF has been identified as the specific binding partner of Nef proteins from HIV-1. Coexpression and binding of these partners initiates profound morphological changes, cytoskeletal rearrangements and the JNK/SAPK signaling cascade, leading to increased levels of viral transcription and replication. [provided by RefSeq]

Human, Mouse

-20°C or -80°C,2°C to 8°C

12352203