Voruciclib

MedChem Express

Voruciclib [1000023-04-0]

5

1000023-04-0

Research Use Only

99.77

C22H19ClF3NO5

469.84

Voruciclib is an orally active and selective CDK inhibitor with K i values of 0.626 nM-9.1 nM. Voruciclib potently blocks CDK9, the transcriptional regulator of MCL-1. Voruciclib represses expression of MCL-1 in multiple models of diffuse large B-cell lymphoma (DLBCL) [1] .

O=C1C=C(C2=CC=C(C(F)(F)F)C=C2Cl)OC3=C([C@H]4[C@H](CO)N(C)CC4)C(O)=CC(O)=C13

-20°C,2°C to 8°C

12352200