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VPS35 antibody [C3], C-term

GTX108058
GeneTex
ApplicationsImmunoFluorescence, ImmunoPrecipitation, Western Blot, ImmunoCytoChemistry, ImmunoHistoChemistry, ImmunoHistoChemistry Paraffin
Product group Antibodies
ReactivityHuman, Mouse, Rat
TargetVPS35
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Overview

  • Supplier
    GeneTex
  • Product Name
    VPS35 antibody [C3], C-term
  • Delivery Days Customer
    9
  • Application Supplier Note
    WB: 1:1000-1:10000. ICC/IF: 1:100-1:1000. IHC-P: 1:100-1:1000. *Optimal dilutions/concentrations should be determined by the researcher.Not tested in other applications.
  • Applications
    ImmunoFluorescence, ImmunoPrecipitation, Western Blot, ImmunoCytoChemistry, ImmunoHistoChemistry, ImmunoHistoChemistry Paraffin
  • Certification
    Research Use Only
  • Clonality
    Polyclonal
  • Concentration
    0.66 mg/ml
  • Conjugate
    Unconjugated
  • Gene ID55737
  • Target name
    VPS35
  • Target description
    VPS35 retromer complex component
  • Target synonyms
    hVPS35; maternal-embryonic 3; MEM3; PARK17; vacuolar protein sorting 35 homolog; vacuolar protein sorting-associated protein 35
  • Host
    Rabbit
  • Isotype
    IgG
  • Protein IDQ96QK1
  • Protein Name
    Vacuolar protein sorting-associated protein 35
  • Scientific Description
    This gene belongs to a group of vacuolar protein sorting (VPS) genes. The encoded protein is a component of a large multimeric complex, termed the retromer complex, involved in retrograde transport of proteins from endosomes to the trans-Golgi network. The close structural similarity between the yeast and human proteins that make up this complex suggests a similarity in function. Expression studies in yeast and mammalian cells indicate that this protein interacts directly with VPS35, which serves as the core of the retromer complex. [provided by RefSeq]
  • Reactivity
    Human, Mouse, Rat
  • Storage Instruction
    -20°C or -80°C,2°C to 8°C
  • UNSPSC
    12352203

References

  • Enhanced Hyaluronan Signaling and Autophagy Dysfunction by VPS35 D620N. Rahman AA et al., 2020 Aug 10, Neuroscience
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  • The Parkinsons Disease Protein LRRK2 Interacts with the GARP Complex to Promote Retrograde Transport to the trans-Golgi Network. Beilina A et al., 2020 May 5, Cell Rep
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  • Phosphorylation of conserved phosphoinositide binding pocket regulates sorting nexin membrane targeting. Lenoir M et al., 2018 Mar 8, Nat Commun
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  • Proteomic analysis reveals novel common genes modulated in both replicative and stress-induced senescence. Succoio M et al., 2015 Oct 14, J Proteomics
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  • VPS35 dysfunction impairs lysosomal degradation of alpha-synuclein and exacerbates neurotoxicity in a Drosophila model of Parkinsons disease. Miura E et al., 2014 Nov, Neurobiol Dis
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