VRK2 Antibody, HRP conjugated

Cusabio

VRK2 Antibody, HRP conjugated

20

ELISA

Research Use Only

Polyclonal

HRP

VRK2

VRK serine/threonine kinase 2

serine/threonine-protein kinase VRK2, vaccinia related kinase 2, vaccinia virus B1R-related kinase 2

Rabbit

IgG

Serine/threonine-protein kinase VRK2

Serine/threonine kinase that regulates several signal transduction pathways. Isoform 1 modulates the stress response to hypoxia and cytokines, such as interleukin-1 beta (IL1B) and this is dependent on its interaction with MAPK8IP1, which assembles mitogen-activated protein kinase (MAPK) complexes. Inhibition of signal transmission mediated by the assembly of MAPK8IP1-MAPK complexes reduces JNK phosphorylation and JUN-dependent transcription. Phosphorylates Thr-18 of p53/TP53, histone H3, and may also phosphorylate MAPK8IP1. Phosphorylates BANF1 and disrupts its ability to bind DNA and reduces its binding to LEM domain-containing proteins. Downregulates the transactivation of transcription induced by ERBB2, HRAS, BRAF, and MEK1. Blocks the phosphorylation of ERK in response to ERBB2 and HRAS. Can also phosphorylate the following substrates that are commonly used to establish in vitro kinase activity: casein, MBP and histone H2B, but it is not sure that this is physiologically relevant.

Human

-20°C or -80°C

41116161