VZ185

Biorbyt

VZ185

10

2306193-61-1

Research Use Only

C53H67FN8O8S

995.2113

VZ185 (VZ-185) is a potent, fast and selective, VHL-based dual degrader probe (PROTAC) of BRD9 and BRD7 with DC50 of 1.8 and 4.5 nM, respectively.

O=C([C@H]1N(C([C@@H](NC(C2(F)CC2)=O)C(C)(C)C)=O)C[C@H](O)C1)NCC3=CC=C(C4=C(C)N=CS4)C=C3OCCCCCN5CCN(CC6=C(OC)C=C(C(C7=CC=NC=C87)=CN(C)C8=O)C=C6OC)CC5

12352200