WHSC2 antibody

GeneTex

WHSC2 antibody

9

Western Blot

Research Use Only

Polyclonal

Unconjugated

NELFA

negative elongation factor complex member A

negative elongation factor A; NELF-A; P/OKcl.15; WHSC2; wolf-Hirschhorn syndrome candidate 2 protein

Chicken

IgY

Negative elongation factor A

WHSC2 is expressed ubiquitously with higher levels in fetal than in adult tissues. Wolf Hirschhorn syndrome (WHS) is a malformation syndrome associated with a hemizygous deletion of the distal short arm of chromosome 4. This gene is mapped to the 165 kb WHS critical region, and may play a role in the phenotype of the WHS or Pitt Rogers Danks syndrome. The encoded protein is found to be capable of reacting with HLA A2 restricted and tumor specific cytotoxic T lymphocytes, suggesting a target for use in specific immunotherapy for a large number of cancer patients. This protein has also been shown to be a member of the NELF (negative elongation factor) protein complex that participates in the regulation of RNA polymerase II transcription elongation.

Human, Mouse, Rat

-20°C or -80°C,2°C to 8°C

12352203