WP1130
27722
CAS Number856243-80-6
Product group Chemicals
Estimated Purity≥98%
Molecular Weight384.3 Da
Overview
- SupplierBPS Bioscience
- Product NameWP1130
- Delivery Days Customer7
- CAS Number856243-80-6
- CertificationResearch Use Only
- Estimated Purity≥98%
- Molecular FormulaC19H18BrN3O
- Molecular Weight384.3 Da
- Scientific DescriptionA partially-selective, cell permeable DUB inhibitor that directly inhibits USP9x, USP5, USP14, and UCH37. WP1130, derived from the tyrphostin AG490, was identified in a screen for molecules that suppress IL-3 and IL-6 activation of STAT molecules. It has been subsequently shown to induce rapid accumulation of polyubiquitinated (K48/K63-linked) proteins into juxtanuclear aggresomes, block JAK2 signaling through JAK2 ubiquitination and subsequent downregulation, and exhibit antiviral activity through activation of the unfolded protein response (UPR). Typical concentration for cell culture experiments is 5 microM.
- UNSPSC12352200