WWTR1 Antibody

Cusabio

WWTR1 Antibody

20

Western Blot, ELISA

Research Use Only

Polyclonal

Unconjugated

WWTR1

WW domain containing transcription regulator 1

TAZ; transcriptional co-activator with PDZ-binding motif; WW domain-containing transcription regulator protein 1

Rabbit

IgG

WW domain-containing transcription regulator protein 1

Transcriptional coactivator which acts as a downstream regulatory target in the Hippo signaling pathway that plays a pivotal role in organ size control and tumor suppression by restricting proliferation and promoting apoptosis. The core of this pathway is composed of a kinase cascade wherein MST1/MST2, in complex with its regulatory protein SAV1, phosphorylates and activates LATS1/2 in complex with its regulatory protein MOB1, which in turn phosphorylates and inactivates YAP1 oncoprotein and WWTR1/TAZ. WWTR1 enhances PAX8 and NKX2-1/TTF1-dependent gene activation. Regulates the nuclear accumulation of SMADS and has a key role in coupling them to the transcriptional machinery such as the mediator complex. Regulates embryonic stem-cell self-renewal, promotes cell proliferation and epithelial-mesenchymal transition. Kanai F., Marignani P.A., Sarbassova D., Yagi R. EMBO J. 19:6778-6791(2000) Lei Q.Y., Zhang H., Zhao B., Zha Z.Y. Mol. Cell. Biol. 28:2426-2436(2008) Varelas X., Sakuma R., Samavarchi-Tehrani P., Peerani R. Nat. Cell Biol. 10:837-848(2008) Di Palma T., DAndrea B., Liguori G.L., Liguoro A. Exp. Cell Res. 315:162-175(2009)

Human, Mouse, Rat

-20°C or -80°C

12352203