WY-14643 [50892-23-4]

AdipoGen Life Sciences

WY-14643

10

50892-23-4

Research Use Only

>98%

Danger

C14H14ClN3O2S

323.8

Chemical. CAS: 50892-23-4. Formula: C14H14ClN3O2S. MW: 323.8. Potent peroxisome proliferator-activated receptor (PPARalpha) activator. Activates also PPARgamma but not PPARdelta. Potent anti-hypercholesterolemic agent. Hypolipidemic compound. Lipogenesis inducer. Tumor promoter. Causes increased cell proliferation and decreased apoptosis. Anti-inflammatory. Inhibits NF-kappaB transcriptional activity and decreases the inflammatory response by reducing the production of inflammatory cytokines (TNF-alpha, IL1beta). Reduces oxidative stress. Increases fatty acid oxidation. Directly affects insulin signaling. Increases glucose uptake. Reviews. - Potent peroxisome proliferator-activated receptor (PPARalpha) activator [1, 2, 7, 9]. Activates also PPARgamma [4, 7] but not PPARdelta [8]. Potent anti-hypercholesterolemic agent [1]. Hypolipidemic compound. Lipogenesis inducer [2, 10]. Tumor promoter [2, 3, 5, 15]. Causes increased cell proliferation and decreased apoptosis [5]. Anti-inflammatory. Inhibits NF-kappaB transcriptional activity and decreases the inflammatory response by reducing the production of inflammatory cytokines (TNF-alpha, IL1beta). Reduces oxidative stress [6, 7, 12, 13]. Increases fatty acid oxidation [11]. Directly affects insulin signaling. Increases glucose uptake [12]. Enhancer of ethanol metabolism. Reviews [5, 11, 14].

CC1=CC=CC(NC2=NC(SCC(O)=O)=NC(Cl)=C2)=C1C

-20°C,2°C to 8°C

12352200