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ProductsBack/XRCC1 antibody [N1N3]

XRCC1 antibody [N1N3]

Research Use Only
GTX111712
GeneTex
ApplicationsImmunoFluorescence, Western Blot, ImmunoCytoChemistry, ImmunoHistoChemistry, ImmunoHistoChemistry Paraffin
DownloadDatasheet
Product group Antibodies
ReactivityHuman, Rat
TargetXRCC1
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Overview

  • Supplier
    GeneTex
  • Product Name
    XRCC1 antibody [N1N3]
  • Delivery Days Customer
    9
  • Application Supplier Note
    WB: 1:500-1:3000. ICC/IF: 1:100-1:1000. IHC-P: 1:100-1:1000. *Optimal dilutions/concentrations should be determined by the researcher.Not tested in other applications.
  • Applications
    ImmunoFluorescence, Western Blot, ImmunoCytoChemistry, ImmunoHistoChemistry, ImmunoHistoChemistry Paraffin
  • Certification
    Research Use Only
  • Clonality
    Polyclonal
  • Concentration
    0.73 mg/ml
  • Conjugate
    Unconjugated
  • Formulation
    Liquid
  • Gene ID7515
  • Target name
    XRCC1
  • Target description
    X-ray repair cross complementing 1
  • Target synonyms
    DNA repair protein XRCC1; RCC; SCAR26; X-ray repair complementing defective repair in Chinese hamster cells 1; X-ray repair cross-complementing protein 1
  • Host
    Rabbit
  • Isotype
    IgG
  • Protein IDP18887
  • Protein Name
    DNA repair protein XRCC1
  • Scientific Description
    The protein encoded by this gene is involved in the efficient repair of DNA single-strand breaks formed by exposure to ionizing radiation and alkylating agents. This protein interacts with DNA ligase III, polymerase beta and poly (ADP-ribose) polymerase to participate in the base excision repair pathway. It may play a role in DNA processing during meiogenesis and recombination in germ cells. A rare microsatellite polymorphism in this gene is associated with cancer in patients of varying radiosensitivity. [provided by RefSeq]
  • Reactivity
    Human, Rat
  • Storage Instruction
    -20°C or -80°C,2°C to 8°C
  • UNSPSC
    12352203

References

  • Targeting dePARylation selectively suppresses DNA repair-defective and PARP inhibitor-resistant malignancies. Chen SH et al., 2019 Apr, Sci Adv
    Read more
  • The PARP inhibitor olaparib enhances the cytotoxicity of combined gemcitabine, busulfan and melphalan in lymphoma cells. Valdez BC et al., 2017 Nov, Leuk Lymphoma
    Read more
  • Classical non-homologous end-joining pathway utilizes nascent RNA for error-free double-strand break repair of transcribed genes. Chakraborty A et al., 2016 Oct 5, Nat Commun
    Read more