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XRCC1 antibody [N1N3]

Name: XRCC1 antibody [N1N3]
SKU: GTX111712_G10
Availability: BackOrder

GTX111712

ApplicationsImmunoFluorescence, Western Blot, ImmunoCytoChemistry, ImmunoHistoChemistry, ImmunoHistoChemistry Paraffin

Product group Antibodies

TargetXRCC1

Overview

Supplier
GeneTex
Product Name
XRCC1 antibody [N1N3]
Delivery Days Customer
9
Application Supplier Note
WB: 1:500-1:3000. ICC/IF: 1:100-1:1000. IHC-P: 1:100-1:1000. *Optimal dilutions/concentrations should be determined by the researcher.Not tested in other applications.
Applications
ImmunoFluorescence, Western Blot, ImmunoCytoChemistry, ImmunoHistoChemistry, ImmunoHistoChemistry Paraffin
Certification
Research Use Only
Clonality
Polyclonal
Concentration
0.73 mg/ml
Conjugate
Unconjugated
Gene ID7515
Target name
XRCC1
Target description
X-ray repair cross complementing 1
Target synonyms
RCC, SCAR26, DNA repair protein XRCC1, X-ray repair complementing defective repair in Chinese hamster cells 1, X-ray repair cross-complementing protein 1
Host
Rabbit
Isotype
IgG
Protein IDP18887
Protein Name
DNA repair protein XRCC1
Scientific Description
The protein encoded by this gene is involved in the efficient repair of DNA single-strand breaks formed by exposure to ionizing radiation and alkylating agents. This protein interacts with DNA ligase III, polymerase beta and poly (ADP-ribose) polymerase to participate in the base excision repair pathway. It may play a role in DNA processing during meiogenesis and recombination in germ cells. A rare microsatellite polymorphism in this gene is associated with cancer in patients of varying radiosensitivity. [provided by RefSeq]
Storage Instruction
-20°C or -80°C,2°C to 8°C
UNSPSC
12352203

Chen SH, Yu X. Targeting dePARylation selectively suppresses DNA repair-defective and PARP inhibitor-resistant malignancies. Sci Adv. 2019,5(4):eaav4340. doi: 10.1126/sciadv.aav4340
Read this paper
Valdez BC, Li Y, Murray D, et al. The PARP inhibitor olaparib enhances the cytotoxicity of combined gemcitabine, busulfan and melphalan in lymphoma cells. Leuk Lymphoma. 2017,58(11):2705-2716. doi: 10.1080/10428194.2017.1306647
Read this paper
Chakraborty A, Tapryal N, Venkova T, et al. Classical non-homologous end-joining pathway utilizes nascent RNA for error-free double-strand break repair of transcribed genes. Nat Commun. 2016,7:13049. doi: 10.1038/ncomms13049
Read this paper