Y-27632 . dihydrochloride [129830-38-2]

AdipoGen Life Sciences

Y-27632 . dihydrochloride

10

129830-38-2

Research Use Only

>98%

Warning

C14H21N3O . 2HCl

247.3 . 72.9

Chemical. CAS: 129830-38-2 - 146986-50-7 (free base). Formula: C14H21N3O . 2HCl. MW: 247.3 . 72.9. Potent, cell permeable, selective and ATP-competitive Rho-associated protein kinases inhibitor, including p160ROCK, ROCK-II and PRK2 inhibitor. Tumor cell invasion and metastasis suppressor. Smooth muscle relaxant. Decreases liver fibrosis by hepatic stellate cell growth inhibition. Antinociceptive. Blocks generation of inflammatory cytokines. Stem cell research modulator. Prevents apoptosis and enhances the survival and cloning efficiency of dissociated human embryonic stem (hES) cells without affecting their pluripotency. Increases survival rate of hES cells undergoing cryopreservation. - Potent, cell permeable, selective and ATP-competitive Rho-associated protein kinases inhibitor, including p160ROCK, ROCK-II and PRK2 inhibitor [1,3-5]. Tumor cell invasion and metastasis suppressor [2, 15]. Smooth muscle relaxant [1, 6]. Decreases liver fibrosis by hepatic stellate cell growth inhibition [7, 8]. Antinociceptive [9]. Blocks generation of inflammatory cytokines [10]. Stem cell research modulator [11-14, 16]. Prevents apoptosis and enhances the survival and cloning efficiency of dissociated human embryonic stem (hES) cells without affecting their pluripotency. Increases survival rate of hES cells undergoing cryopreservation [11-14, 16].

C[C@@H](N)C1CCC(CC1)C(=O)NC1=CC=NC=C1

-20°C,2°C to 8°C

12352200