More than 130 suppliers
ISO certified
In-house tech support
we Connect you
Bio-Connect
ProductsBack/Y-27632 dihydrochloride
Chemical Structure
Chemical Structure
Chemical Structure

Y-27632 dihydrochloride

M1817
AbMole BioScience
CAS Number129830-38-2
DownloadDatasheet
DownloadMSDS
Product group Chemicals
Estimated Purity0.9972
Molecular Weight320.26
Sign in to order and to see your custom pricing.
Large volume orders?
Order with a bulk request
More than 130 suppliers
ISO certified
In-house tech support

Overview

  • Supplier
    AbMole BioScience
  • Product Name
    Y-27632 dihydrochloride
  • Delivery Days Customer
    9
  • CAS Number
    129830-38-2
  • Category Supplier
    Chemical
  • Estimated Purity
    0.9972
  • Molecular Formula
    C14H21N3O.2HCl
  • Molecular Weight
    320.26
  • Scientific Description
    Y-27632 is a potent, selective inhibitor of Rho-associated protein kinases (ROCK) with IC50 values of 140-220 nM for ROCK1 and ROCK2. Y-27632 inhibited the kinase activity of both ROCK-I and ROCK-II in vitro, and this inhibition was reversed by ATP in a competitive manner. The ROCK family of Rho-associated serine-threonine protein kinases is known to play an important role in Rho-mediated cell adhesion and smooth muscle contraction. It also inhibits PRK2 with an IC50 value of 600 nM. One-hour treatment with 10 µM Y-27632 blocks apoptosis of dissociated cultured human embryonic stem cells, increasing cloning efficiency by 25% and sustaining survival up to 30 passages. Y-27632 was found to increases human embryonic stem cell (hESC) survival. In addition, Y-27632 inhibited LPA-induced entosis.
  • SMILES
    Cl.Cl.CC(N)C1CCC(CC1)C(=O)NC2=CC=NC=C2
  • UNSPSC
    12352200

References

  • Borrelli C, Roberts M, Eletto D, et al. In vivo interaction screening reveals liver-derived constraints to metastasis. Nature. 2024;632(8024):411-418.
    Read more
  • Rosendahl Huber A, Pleguezuelos-Manzano C, Puschhof J, et al. Improved detection of colibactin-induced mutations by genotoxic E. coli in organoids and colorectal cancer. Cancer Cell. 2024;42(3):487-496.e6.
    Read more
  • Hendriks D, Pagliaro A, Andreatta F, et al. Human fetal brain self-organizes into long-term expanding organoids. Cell. 2024;187(3):712-732.e38.
    Read more
  • Sharma G, Sharma A, Kim I, et al. A dietary commensal microbe enhances antitumor immunity by activating tumor macrophages to sequester iron. Nat Immunol. 2024;25(5):790-801.
    Read more
  • Bannier-Hélaouët M, Korving J, Ma Z, et al. Human conjunctiva organoids to study ocular surface homeostasis and disease. Cell Stem Cell. 2024;31(2):227-243.e12.
    Read more
  • Qiu Y, Stamatatos OT, Hu Q, et al. The unique catalytic properties of PSAT1 mediate metabolic adaptation to glutamine blockade. Nat Metab. 2024;6(8):1529-1548.
    Read more
  • Fan G, Yu B, Tang L, et al. TSPAN8+ myofibroblastic cancer-associated fibroblasts promote chemoresistance in patients with breast cancer. Sci Transl Med. 2024;16(741):eadj5705.
    Read more
  • Kim WK, Buckley AJ, Lee DH, et al. Androgen deprivation induces double-null prostate cancer via aberrant nuclear export and ribosomal biogenesis through HGF and Wnt activation. Nat Commun. 2024;15(1):1231.
    Read more
  • Li Y, Jiang M, Aye L, et al. UPP1 promotes lung adenocarcinoma progression through the induction of an immunosuppressive microenvironment. Nat Commun. 2024;15(1):1200.
    Read more
  • Hendriks D, Artegiani B, Margaritis T, Zoutendijk I, Chuva de Sousa Lopes S, Clevers H. Mapping of mitogen and metabolic sensitivity in organoids defines requirements for human hepatocyte growth. Nat Commun. 2024;15(1):4034.
    Read more