Y134 [849662-80-2]

TargetMol Chemicals

Y134 [849662-80-2]

4

849662-80-2

Research Use Only

Y134

99.72%

C28H28N2O3S

472.6

Y134 is an estrogen receptor inhibitor that is selective and orally active, exhibiting strong antagonist activity against ERalpha and Erbeta with Ki of 0.09 nM and 11.31 nM, respectively. The selectivity of Y134 for ERalpha is 121.1 times higher than that for ERbeta. Y134 inhibited the proliferation of ER positive human breast cancer cells stimulated by estrogen.

3 years

C(=O)(C1=C(SC=2C1=CC=C(O)C2)C3=CC=C(O)C=C3)C4=CC=C(C=C4)N5CCN(C(C)C)CC5

-20°C

12352200