YKL-05-099

AbMole BioScience

YKL-05-099

9

1936529-65-5

Chemical

Research Use Only

600.11

YKL-05-099 is a salt-inducible kinase (SIK) inhibitor. YKL-05-099 binds to SIK1 and SIK3 with IC50s of ~10 and ~30 nM, respectively. YKL-05-099 has slightly less potent SIK2-inhibitory (IC50=40 nM).

COC1=CN=C(C=C1)N2C(=O)N(CC3=CN=C(NC4=CC=C(C=C4OC)C5CCN(C)CC5)N=C23)C6=C(C)C=CC=C6Cl

12352200