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YKL-5-124

HY-101257
MedChem Express
CAS Number1957203-01-8
Product group Chemicals
Estimated Purity98.79
Molecular Weight515.61
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Overview

  • Supplier
    MedChem Express
  • Product Name
    YKL-5-124 [1957203-01-8]
  • Delivery Days Customer
    10
  • CAS Number
    1957203-01-8
  • Estimated Purity
    98.79
  • Molecular Formula
    C28H33N7O3
  • Molecular Weight
    515.61
  • Scientific Description
    YKL-5-124 is a potent, selective, irreversible and covalent CDK7 inhibitor with IC 50 s of 53.5 nM and 9.7 nM for CDK7 and CDK7/Mat1/CycH , respectively. YKL-5-124 is >100-fold greater selective for CDK7 than CDK9 and CDK2, and inactive against CDK12 and CDK13. YKL-5-124 induces a strong cell-cycle arrest, inhibits E2F-driven gene expression, and exhibits little effect on RNA polymerase II phosphorylation status [1] .
  • SMILES
    CC1(C)N(C(N[C@@H](C2=CC=CC=C2)CN(C)C)=O)CC3=C1NN=C3NC(C4=CC=C(NC(C=C)=O)C=C4)=O
  • Storage Instruction
    -20°C,2°C to 8°C
  • UNSPSC
    12352200