YQ128

MedChem Express

YQ128 [2454246-18-3]

10

2454246-18-3

Research Use Only

99.83

C27H29ClN2O4S2

545.11

YQ128 is a potent and selective second-generation NLRP3 (NOD-like receptor P3) inflammasome inhibitor with an IC50 of 0.30 microM. YQ128 significantly and selectively suppresses the production of IL-1beta, but not TNF-alpha, and it can cross the BBB to reach the CNS. YQ128 has anti-inflammatory activity[1]. YQ128 is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.

O=S(C1=CC=C(CCN(CC2=C(C=CC(Cl)=C2)OCCC)C(CC3=CSC=C3)=O)C=C1)(NCC#C)=O

-20°C,2°C to 8°C

12352200