Z-Leu-Leu-Nva-CHO [MG-115] [133407-86-0]

Name: Z-Leu-Leu-Nva-CHO [MG-115] [133407-86-0]
SKU: AG-CP3-0015_A27
Availability: BackOrder

AG-CP3-0015

CAS Number133407-86-0

Product group Chemicals

Estimated Purity>95%

Molecular Weight461.6

Overview

Supplier
AdipoGen Life Sciences
Product Name
Z-Leu-Leu-Nva-CHO [MG-115]
Delivery Days Customer
10
CAS Number
133407-86-0
Certification
Research Use Only
Estimated Purity
>95%
Molecular Formula
C25H39N3O5
Molecular Weight
461.6
Scientific Description
Chemical. CAS: 133407-86-0. Formula: C25H39N3O5. MW: 461.6. Potent, reversible and cell permeable proteasome inhibitor. Specifically inhibits the chymotrypsin-like activity of the proteasome. Calpain and cathepsin inhibitor. Apoptosis inducer in Rat-1 and PC12 cells via a p53-dependent pathway. Autophagy activator. - Potent, reversible and cell permeable proteasome inhibitor. Specifically inhibits the chymotrypsin-like activity of the proteasome. Calpain and cathepsin inhibitor. Apoptosis inducer in Rat-1 and PC12 cells via a p53-dependent pathway. Autophagy activator.
SMILES
[H]C(=O)[C@H](CCC)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC(C)C)NC(=O)OCC1=CC=CC=C1
Storage Instruction
-20°C,2°C to 8°C
UNSPSC
51202000

Potent and selective inhibitors of the proteasome: dipeptidyl boronic acids: J. Adams, et al.; Bioorg. Med. Chem. Lett. 17, 333 (1998)
Ubiquitination of E3 ubiquitin ligase TRIM5 alpha and its potential role: K. Yamauchi, et al.; FEBS J. 275, 1540 (2008)
Proteasome inhibition induces stress kinase dependent transport deficits-implications for Alzheimer's disease: L. Agholme, et al.; Mol. Cell Neurosci. 58, 29 (2014)