Western blot analysis of extracts of various cell lines using ZAP70 Polyclonal Antibody at 1:1000 dilution.
Western blot analysis of extracts of various cell lines using ZAP70 Polyclonal Antibody at 1:1000 dilution.
ZAP70 Polyclonal Antibody
E-AB-60677
Product group Antibodies
Overview
- SupplierElabscience
- Product NameZAP70 Polyclonal Antibody
- Delivery Days Customer12
- CertificationResearch Use Only
- Scientific DescriptionThis gene encodes an enzyme belonging to the protein tyrosine kinase family, and it plays a role in T-cell development and lymphocyte activation. This enzyme, which is phosphorylated on tyrosine residues upon T-cell antigen receptor (TCR) stimulation, functions in the initial step of TCR-mediated signal transduction in combination with the Src family kinases, Lck and Fyn. This enzyme is also essential for thymocyte development. Mutations in this gene cause selective T-cell defect, a severe combined immunodeficiency disease characterized by a selective absence of CD8-positive T-cells. Two transcript variants that encode different isoforms have been found for this gene.
- UNSPSC12352203