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ZC3H12A antibody [N3C3]

Name: ZC3H12A antibody [N3C3]
SKU: GTX110807_G10
Availability: BackOrder

GTX110807

ApplicationsFlow Cytometry, ImmunoFluorescence, ImmunoPrecipitation, Western Blot, ImmunoCytoChemistry, ImmunoHistoChemistry

Product group Antibodies

ReactivityHuman, Mouse

TargetZC3H12A

Overview

Supplier
GeneTex
Product Name
ZC3H12A antibody [N3C3]
Delivery Days Customer
9
Application Supplier Note
WB: 1:500-1:3000. ICC/IF: 1:100-1:1000. *Optimal dilutions/concentrations should be determined by the researcher.Not tested in other applications.
Applications
Flow Cytometry, ImmunoFluorescence, ImmunoPrecipitation, Western Blot, ImmunoCytoChemistry, ImmunoHistoChemistry
Certification
Research Use Only
Clonality
Polyclonal
Concentration
0.5 mg/ml
Conjugate
Unconjugated
Gene ID80149
Target name
ZC3H12A
Target description
zinc finger CCCH-type containing 12A
Target synonyms
MCPIP, MCPIP-1, MCPIP1, Reg1, dJ423B22.1, endoribonuclease ZC3H12A, MCP-1 treatment-induced protein, MCP-induced protein 1, bifunctional endoribonuclease and deubiquitinase ZC3H12A, monocyte chemotactic protein-induced protein 1, regnase-1, ribonuclease ZC3H12A, zinc finger CCCH domain-containing protein 12A
Host
Rabbit
Isotype
IgG
Protein IDQ5D1E8
Protein Name
Endoribonuclease ZC3H12A
Scientific Description
ZC3H12A is an MCP1 (CCL2; MIM 158105)-induced protein that acts as a transcriptional activator and causes cell death of cardiomyocytes, possibly via induction of genes associated with apoptosis.[supplied by OMIM]
Reactivity
Human, Mouse
Storage Instruction
-20°C or -80°C,2°C to 8°C
UNSPSC
12352203

References

Gorka J, Marona P, Kwapisz O, et al. MCPIP1 regulates focal adhesion kinase and Rho GTPase-dependent migration in clear cell renal cell carcinoma. Eur J Pharmacol. 2022,922:174804. doi: 10.1016/j.ejphar.2022.174804
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Krajewski PK, Szukała W, Lichawska-Cieślar A, et al. MCPIP1/Regnase-1 Expression in Keratinocytes of Patients with Hidradenitis Suppurativa: Preliminary Results. Int J Mol Sci. 2021,22(14). doi: 10.3390/ijms22147241
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Gasiorek A, Dobosz E, Potempa B, et al. Subversion of Lipopolysaccharide Signaling in Gingival Keratinocytes via MCPIP-1 Degradation as a Novel Pathogenic Strategy of Inflammophilic Pathobionts. mBio. 2021,12(3):e0050221. doi: 10.1128/mBio.00502-21
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Tomita T, Kato M, Mishima T, et al. Extracellular mRNA transported to the nucleus exerts translation-independent function. Nat Commun. 2021,12(1):3655. doi: 10.1038/s41467-021-23969-1
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Chen F, Wang Q, Yu X, et al. MCPIP1-mediated NFIC alternative splicing inhibits proliferation of triple-negative breast cancer via cyclin D1-Rb-E2F1 axis. Cell Death Dis. 2021,12(4):370. doi: 10.1038/s41419-021-03661-4
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Kook I, Ziegelbauer JM. Monocyte chemoattractant protein-induced protein 1 directly degrades viral miRNAs with a specific motif and inhibits KSHV infection. Nucleic Acids Res. 2021,49(8):4456-4471. doi: 10.1093/nar/gkab215
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Li Y, Que L, Fukano K, et al. MCPIP1 reduces HBV-RNA by targeting its epsilon structure. Sci Rep. 2020,10(1):20763. doi: 10.1038/s41598-020-77166-z
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Gorka J, Marona P, Kwapisz O, et al. The anti-inflammatory protein MCPIP1 inhibits the development of ccRCC by maintaining high levels of tumour suppressors. Eur J Pharmacol. 2020,888:173591. doi: 10.1016/j.ejphar.2020.173591
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Li M, Yang J, Zhao Y, et al. MCPIP1 inhibits Hepatitis B virus replication by destabilizing viral RNA and negatively regulates the virus-induced innate inflammatory responses. Antiviral Res. 2020,174:104705. doi: 10.1016/j.antiviral.2020.104705
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Losko M, Dolicka D, Pydyn N, et al. Integrative genomics reveal a role for MCPIP1 in adipogenesis and adipocyte metabolism. Cell Mol Life Sci. 2020,77(23):4899-4919. doi: 10.1007/s00018-019-03434-5
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ZC3H12A antibody [N3C3]

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