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ProductsBack/ZC3H12A antibody [N3C3]

ZC3H12A antibody [N3C3]

GTX110807
GeneTex
ApplicationsFlow Cytometry, ImmunoFluorescence, ImmunoPrecipitation, Western Blot, ImmunoCytoChemistry, ImmunoHistoChemistry
Product group Antibodies
TargetZC3H12A
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Overview

  • Supplier
    GeneTex
  • Product Name
    ZC3H12A antibody [N3C3]
  • Delivery Days Customer
    9
  • Application Supplier Note
    WB: 1:500-1:3000. ICC/IF: 1:100-1:1000. *Optimal dilutions/concentrations should be determined by the researcher.Not tested in other applications.
  • Applications
    Flow Cytometry, ImmunoFluorescence, ImmunoPrecipitation, Western Blot, ImmunoCytoChemistry, ImmunoHistoChemistry
  • Certification
    Research Use Only
  • Clonality
    Polyclonal
  • Concentration
    0.5 mg/ml
  • Conjugate
    Unconjugated
  • Gene ID80149
  • Target name
    ZC3H12A
  • Target description
    zinc finger CCCH-type containing 12A
  • Target synonyms
    MCPIP, MCPIP-1, MCPIP1, Reg1, dJ423B22.1, endoribonuclease ZC3H12A, MCP-1 treatment-induced protein, MCP-induced protein 1, bifunctional endoribonuclease and deubiquitinase ZC3H12A, monocyte chemotactic protein-induced protein 1, regnase-1, ribonuclease ZC3H12A, zinc finger CCCH domain-containing protein 12A
  • Host
    Rabbit
  • Isotype
    IgG
  • Protein IDQ5D1E8
  • Protein Name
    Endoribonuclease ZC3H12A
  • Scientific Description
    ZC3H12A is an MCP1 (CCL2; MIM 158105)-induced protein that acts as a transcriptional activator and causes cell death of cardiomyocytes, possibly via induction of genes associated with apoptosis.[supplied by OMIM]
  • Storage Instruction
    -20°C or -80°C,2°C to 8°C
  • UNSPSC
    12352203

References

  • Gorka J, Marona P, Kwapisz O, et al. MCPIP1 regulates focal adhesion kinase and Rho GTPase-dependent migration in clear cell renal cell carcinoma. Eur J Pharmacol. 2022,922:174804. doi: 10.1016/j.ejphar.2022.174804
    Read this paper
  • Krajewski PK, Szukała W, Lichawska-Cieślar A, et al. MCPIP1/Regnase-1 Expression in Keratinocytes of Patients with Hidradenitis Suppurativa: Preliminary Results. Int J Mol Sci. 2021,22(14). doi: 10.3390/ijms22147241
    Read this paper
  • Gasiorek A, Dobosz E, Potempa B, et al. Subversion of Lipopolysaccharide Signaling in Gingival Keratinocytes via MCPIP-1 Degradation as a Novel Pathogenic Strategy of Inflammophilic Pathobionts. mBio. 2021,12(3):e0050221. doi: 10.1128/mBio.00502-21
    Read this paper
  • Tomita T, Kato M, Mishima T, et al. Extracellular mRNA transported to the nucleus exerts translation-independent function. Nat Commun. 2021,12(1):3655. doi: 10.1038/s41467-021-23969-1
    Read this paper
  • Chen F, Wang Q, Yu X, et al. MCPIP1-mediated NFIC alternative splicing inhibits proliferation of triple-negative breast cancer via cyclin D1-Rb-E2F1 axis. Cell Death Dis. 2021,12(4):370. doi: 10.1038/s41419-021-03661-4
    Read this paper
  • Kook I, Ziegelbauer JM. Monocyte chemoattractant protein-induced protein 1 directly degrades viral miRNAs with a specific motif and inhibits KSHV infection. Nucleic Acids Res. 2021,49(8):4456-4471. doi: 10.1093/nar/gkab215
    Read this paper
  • Li Y, Que L, Fukano K, et al. MCPIP1 reduces HBV-RNA by targeting its epsilon structure. Sci Rep. 2020,10(1):20763. doi: 10.1038/s41598-020-77166-z
    Read this paper
  • Gorka J, Marona P, Kwapisz O, et al. The anti-inflammatory protein MCPIP1 inhibits the development of ccRCC by maintaining high levels of tumour suppressors. Eur J Pharmacol. 2020,888:173591. doi: 10.1016/j.ejphar.2020.173591
    Read this paper
  • Li M, Yang J, Zhao Y, et al. MCPIP1 inhibits Hepatitis B virus replication by destabilizing viral RNA and negatively regulates the virus-induced innate inflammatory responses. Antiviral Res. 2020,174:104705. doi: 10.1016/j.antiviral.2020.104705
    Read this paper
  • Losko M, Dolicka D, Pydyn N, et al. Integrative genomics reveal a role for MCPIP1 in adipogenesis and adipocyte metabolism. Cell Mol Life Sci. 2020,77(23):4899-4919. doi: 10.1007/s00018-019-03434-5
    Read this paper

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Figure 1. Western blot analysis of MCPIP1/ZC3H12A using anti-MCPIP1/ZC3H12A antibody (A01688-2). Electrophoresis was performed on a 5-20% SDS-PAGE gel at 70V (Stacking gel) / 90V (Resolving gel) for 2-3 hours. The sample well of each lane was loaded with 50ug of sample under reducing conditions. Lane 1: human K562 whole cell lysates, Lane 2: human Raji whole cell lysates, Lane 3: human Sw620 whole cell lysates, Lane 4: human Hela whole cell lysates, Lane 4: rat spleen tissue lysates, Lane 5: rat kidney tissue lysates, Lane 6: mouse thymus tissue lysates. After Electrophoresis, proteins were transferred to a Nitrocellulose membrane at 150mA for 50-90 minutes. Blocked the membrane with 5% Non-fat Milk/ TBS for 1.5 hour at RT. The membrane was incubated with rabbit anti-MCPIP1/ZC3H12A antigen affinity purified polyclonal antibody (Catalog # A01688-2) at 0.5 microg/mL overnight at 4°C, then washed with TBS-0.1%Tween 3 times with 5 minutes each and probed with a goat anti-rabbit IgG-HRP secondary antibody at a dilution of 1:5000 for 1.5 hour at RT. The signal is developed using an Enhanced Chemiluminescent detection (ECL) kit (Catalog # EK1002) with Tanon 5200 system. A specific band was detected for MCPIP1/ZC3H12A at approximately 73KD. The expected band size for MCPIP1/ZC3H12A is at 66KD.
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