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ProductsBack/ZC3H12A antibody [N3C3]

ZC3H12A antibody [N3C3]

Research Use Only
GTX110807
GeneTex
ApplicationsFlow Cytometry, ImmunoFluorescence, ImmunoPrecipitation, Western Blot, ImmunoCytoChemistry, ImmunoHistoChemistry
DownloadDatasheet
Product group Antibodies
ReactivityHuman
TargetZC3H12A
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Overview

  • Supplier
    GeneTex
  • Product Name
    ZC3H12A antibody [N3C3]
  • Delivery Days Customer
    9
  • Antibody Specificity
    Knockdown/Knockout validation was supported by references (PMID:27322373)
  • Application Supplier Note
    WB: 1:500-1:3000. ICC/IF: 1:100-1:1000. *Optimal dilutions/concentrations should be determined by the researcher.Not tested in other applications.
  • Applications
    Flow Cytometry, ImmunoFluorescence, ImmunoPrecipitation, Western Blot, ImmunoCytoChemistry, ImmunoHistoChemistry
  • Certification
    Research Use Only
  • Clonality
    Polyclonal
  • Concentration
    0.5 mg/ml
  • Conjugate
    Unconjugated
  • Formulation
    Liquid
  • Gene ID80149
  • Target name
    ZC3H12A
  • Target description
    zinc finger CCCH-type containing 12A
  • Target synonyms
    bifunctional endoribonuclease and deubiquitinase ZC3H12A; dJ423B22.1; endoribonuclease ZC3H12A; MCP-1 treatment-induced protein; MCP-induced protein 1; MCPIP; MCPIP1; MCPIP-1; monocyte chemotactic protein-induced protein 1; Reg1; regnase-1; ribonuclease ZC3H12A; zinc finger CCCH domain-containing protein 12A
  • Host
    Rabbit
  • Isotype
    IgG
  • Protein IDQ5D1E8
  • Protein Name
    Endoribonuclease ZC3H12A
  • Scientific Description
    ZC3H12A is an MCP1 (CCL2; MIM 158105)-induced protein that acts as a transcriptional activator and causes cell death of cardiomyocytes, possibly via induction of genes associated with apoptosis.[supplied by OMIM]
  • Reactivity
    Human
  • Storage Instruction
    -20°C or -80°C,2°C to 8°C
  • UNSPSC
    12352203

References

  • MCPIP1 regulates focal adhesion kinase and Rho GTPase-dependent migration in clear cell renal cell carcinoma. Gorka J et al., 2022 May 5, Eur J Pharmacol
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  • MCPIP1/Regnase-1 Expression in Keratinocytes of Patients with Hidradenitis Suppurativa: Preliminary Results. Krajewski PK et al., 2021 Jul 6, Int J Mol Sci
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  • Subversion of Lipopolysaccharide Signaling in Gingival Keratinocytes via MCPIP-1 Degradation as a Novel Pathogenic Strategy of Inflammophilic Pathobionts. Gasiorek A et al., 2021 Jun 29, mBio
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  • Extracellular mRNA transported to the nucleus exerts translation-independent function. Tomita T et al., 2021 Jun 16, Nat Commun
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  • MCPIP1-mediated NFIC alternative splicing inhibits proliferation of triple-negative breast cancer via cyclin D1-Rb-E2F1 axis. Chen F et al., 2021 Apr 6, Cell Death Dis
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  • Monocyte chemoattractant protein-induced protein 1 directly degrades viral miRNAs with a specific motif and inhibits KSHV infection. Kook I et al., 2021 May 7, Nucleic Acids Res
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  • MCPIP1 reduces HBV-RNA by targeting its epsilon structure. Li Y et al., 2020 Nov 27, Sci Rep
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  • The anti-inflammatory protein MCPIP1 inhibits the development of ccRCC by maintaining high levels of tumour suppressors. Gorka J et al., 2020 Dec 5, Eur J Pharmacol
    Read more
  • MCPIP1 inhibits Hepatitis B virus replication by destabilizing viral RNA and negatively regulates the virus-induced innate inflammatory responses. Li M et al., 2020 Feb, Antiviral Res
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  • Integrative genomics reveal a role for MCPIP1 in adipogenesis and adipocyte metabolism. Losko M et al., 2020 Dec, Cell Mol Life Sci
    Read more