Zotatifin

MedChem Express

Zotatifin [2098191-53-6]

10

2098191-53-6

Research Use Only

99.69

C28H29N3O5

487.55

Zotatifin (eFT226) is a potent, selective, and well-tolerated eIF4A inhibitor. Zotatifin promotes eIF4A binding to specific mRNA sequences with recognition motifs in the 5-UTRs ( IC 50 =2 nM) and interferes with the assembly of the eIF4F initiation complex [1] . Zotatifin shows robust antiviral effects, it effectively reduces viral infectivity by inhibiting SARS-CoV-2 NP protein biogenesis ( IC 90 =37 nM) [2] . Zotatifin induces cell apoptosis [1] .

N#CC1=CC=C([C@@]2(O3)[C@@](C4=C3C=C(OC)N=C4OC)(O)[C@H](O)[C@H](CN(C)C)[C@H]2C5=CC=CC=C5)C=C1

-20°C,2°C to 8°C

12352200