Zotatifin [2098191-53-6]

MedChem Express

Zotatifin [2098191-53-6]

10

2098191-53-6

Research Use Only

99.46%

C28H29N3O5

487.55

Zotatifin (eFT226) is a potent, selective, and well-tolerated eIF4A inhibitor. Zotatifin promotes eIF4A binding to specific mRNA sequences with recognition motifs in the 5-UTRs (IC50=2 nM) and interferes with the assembly of the eIF4F initiation complex. Zotatifin shows robust antiviral effects, it effectively reduces viral infectivity by inhibiting SARS-CoV-2 NP protein biogenesis (IC90=37 nM). Zotatifin induces cell apoptosis.

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2°C to 8°C,-20°C,-80°C

12352200