Zotatifin [2098191-53-6]

TargetMol Chemicals

Zotatifin [2098191-53-6]

114

2098191-53-6

Chemical

Research Use Only

Zotatifin

C28H29N3O5

487.55

Zotatifin is a potent and well-tolerated eIF4A inhibitor. Zotatifin promotes eIF4A binding to specific mRNA sequences with recognition motifs in the 5-UTRs (IC50=2 nM). Zotatifin effectively reduces viral infectivity by inhibiting SARS-CoV-2 NP protein biogenesis (IC90=37 nM).

3 years

COc1cc2O[C@]3([C@@H]([C@@H](CN(C)C)[C@@H](O)[C@@]3(O)c2c(OC)n1)c1ccccc1)c1ccc(cc1)C#N

-20°C

12352200