Confocal immunofluorescence analysis (Olympus FV10i) of paraformaldehyde-fixed 293T, using ZWINT(GTX107155) antibody (Green) at 1:500 dilution. Alpha-tubulin filaments were labeled with GTX11304 (Red) at 1:500.

ZWINT antibody

Name: ZWINT antibody
SKU: GTX107155_G10
Availability: BackOrder

GTX107155

ApplicationsImmunoFluorescence, Western Blot, ImmunoCytoChemistry

Product group Antibodies

ReactivityHuman

TargetZWINT

Overview

Supplier
GeneTex
Product Name
ZWINT antibody
Delivery Days Customer
9
Application Supplier Note
WB: 1:500-1:3000. ICC/IF: 1:100-1:1000. *Optimal dilutions/concentrations should be determined by the researcher.Not tested in other applications.
Applications
ImmunoFluorescence, Western Blot, ImmunoCytoChemistry
Certification
Research Use Only
Clonality
Polyclonal
Concentration
1 mg/ml
Conjugate
Unconjugated
Gene ID11130
Target name
ZWINT
Target description
ZW10 interacting kinetochore protein
Target synonyms
HZwint-1, KNTC2AP, SIP30, ZWINT1, outer kinetochore KNL1 complex subunit ZWINT, SNAP25 interacting protein of 30 kDa, ZW10 interactor, kinetochore protein, human ZW10 interacting protein-1, zwint-1
Host
Rabbit
Isotype
IgG
Protein IDO95229
Protein Name
Outer kinetochore KNL1 complex subunit ZWINT
Scientific Description
This gene encodes a protein that is clearly involved in kinetochore function although an exact role is not known. It interacts with ZW10, another kinetochore protein, possibly regulating the association between ZW10 and kinetochores. The encoded protein localizes to prophase kinetochores before ZW10 does and it remains detectable on the kinetochore until late anaphase. It has a uniform distribution in the cytoplasm of interphase cells. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq]
Reactivity
Human
Storage Instruction
-20°C or -80°C,2°C to 8°C
UNSPSC
12352203

References

Kim JH, Youn Y, Lee JC, et al. Involvement of the NF-κB signaling pathway in proliferation and invasion inhibited by Zwint-1 deficiency in Pancreatic Cancer Cells. J Cancer. 2020,11(19):5601-5611. doi: 10.7150/jca.46173
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Zhou H, Wang T, Zheng T, et al. Cep57 is a Mis12-interacting kinetochore protein involved in kinetochore targeting of Mad1-Mad2. Nat Commun. 2016,7:10151. doi: 10.1038/ncomms10151
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Wei R, Ngo B, Wu G, et al. Phosphorylation of the Ndc80 complex protein, HEC1, by Nek2 kinase modulates chromosome alignment and signaling of the spindle assembly checkpoint. Mol Biol Cell. 2011,22(19):3584-94. doi: 10.1091/mbc.E11-01-0012
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ZWINT antibody

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Overview

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