(+/-)12-HEPE [81187-21-5]
HY-117044A
CAS Number81187-21-5
Product group Chemicals
Molecular Weight318.45
Overview
- SupplierMedChem Express
- Product Name(+/-)12-HEPE [81187-21-5]
- Delivery Days Customer5
- CAS Number81187-21-5
- CertificationResearch Use Only
- Molecular FormulaC20H30O3
- Molecular Weight318.45
- Scientific Description(+/-)12-HEPE is produced by non-enzymatic oxidation of EPA. It contains equal amounts of 12(S)-HEPE and 12(R)-HEPE. The biological activity of (+/-)12-HEPE is likely mediated by one of the individual isomers, most commonly the 12(S) isomer in mammalian systems. 12-HEPE inhibits platelet aggregation with the same potency as 12-HETE, exhibiting IC50 values of 24 and 25 microM, respectively.1 These compounds are also equipotent as inhibitors of U46619-induced contraction of rat aorta (IC50s=8.6-8.8 microM).
- SMILESCC/C=C\C/C=C\CC(O)/C=C/C=C\C/C=C\CCCC(O)=O
- UNSPSC12352200
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