Bio-Connect

(+/-)12-HEPE [81187-21-5]

HY-117044A
MedChem Express
CAS Number81187-21-5
Product group Chemicals
Molecular Weight318.45
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Overview

  • Supplier
    MedChem Express
  • Product Name
    (+/-)12-HEPE [81187-21-5]
  • Delivery Days Customer
    5
  • CAS Number
    81187-21-5
  • Certification
    Research Use Only
  • Molecular Formula
    C20H30O3
  • Molecular Weight
    318.45
  • Scientific Description
    (+/-)12-HEPE is produced by non-enzymatic oxidation of EPA. It contains equal amounts of 12(S)-HEPE and 12(R)-HEPE. The biological activity of (+/-)12-HEPE is likely mediated by one of the individual isomers, most commonly the 12(S) isomer in mammalian systems. 12-HEPE inhibits platelet aggregation with the same potency as 12-HETE, exhibiting IC50 values of 24 and 25 microM, respectively.1 These compounds are also equipotent as inhibitors of U46619-induced contraction of rat aorta (IC50s=8.6-8.8 microM).
  • SMILES
    CC/C=C\C/C=C\CC(O)/C=C/C=C\C/C=C\CCCC(O)=O
  • UNSPSC
    12352200