7alpha,25-Dihydroxycholesterol

MedChem Express

7alpha,25-Dihydroxycholesterol [64907-22-8]

10

64907-22-8

Research Use Only

99.88

C27H46O3

418.65

7alpha, 25-dihydroxycholesterol (7alpha,25-OHC) is a potent and selective agonist and endogenous ligand of the orphan GPCR receptor EBI2 (GPR183) . 7alpha, 25-dihydroxycholesterol is highly potent at activating EBI2 ( EC 50 =140 pM; K d =450 pM). 7alpha, 25-dihydroxycholesterol can serve as a chemokine directing migration of B cells, T cells and dendritic cells [1] [2] .

C[C@@]12[C@](CC[C@]2([H])[C@H](C)CCCC(C)(O)C)([H])[C@@]3([H])[C@]([C@@]4(C(C[C@@H](O)CC4)=C[C@H]3O)C)([H])CC1

-20°C

12352200