7alpha,25-Dihydroxycholesterol [64907-22-8]

TargetMol Chemicals

7alpha,25-Dihydroxycholesterol [64907-22-8]

44

64907-22-8

Chemical

Research Use Only

7alfa,25-Dihydroxycholesterol

C27H46O3

418.65

7alpha,25-dihydroxycholesterol (7alpha,25-OHC) is a potent and selective agonist, as well as an endogenous ligand, of the orphan GPCR receptor EBI2 (GPR183). It serves as a chemokine directing the migration of B cells, T cells, and dendritic cells and exhibits high potency in activating EBI2 (EC50=140 pM; Kd=450 pM) [1][2].

3 years

C[C@H](CCCC(C)(C)O)[C@H]1CC[C@H]2[C@@H]3[C@H](O)C=C4C[C@@H](O)CC[C@]4(C)[C@H]3CC[C@]12C

-20°C

12352200