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A-366

HY-12583
MedChem Express
CAS Number1527503-11-2
DownloadMSDS
Product group Chemicals
Estimated Purity98.01
Molecular Weight329.44
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Overview

  • Supplier
    MedChem Express
  • Product Name
    A-366 [1527503-11-2]
  • Delivery Days Customer
    10
  • CAS Number
    1527503-11-2
  • Certification
    Research Use Only
  • Estimated Purity
    98.01
  • Molecular Formula
    C19H27N3O2
  • Molecular Weight
    329.44
  • Scientific Description
    A-366 is a potent, highly selective, peptide-competitive histone methyltransferase G9a inhibitor with IC 50 s of 3.3 and 38 nM for G9a and GLP (EHMT1), respectively. A-366 shows >1000-fold selectivity over 21 other methyltransferases. A-366 is also a potent, nanomolar inhibitor of the Spindlin1-H3K4me3-interaction (IC 50 =182.6 nM). A-366 displays high affinity at human histamine H3 receptor (K i =17 nM) and shows subtype selectivity among subsets of the histaminergic and dopaminergic receptor families [1] [2] [3] [4] .
  • SMILES
    COC1=CC2=C(N=C(N)C23CCC3)C=C1OCCCN4CCCC4
  • Storage Instruction
    -20°C,2°C to 8°C
  • UNSPSC
    12352200