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A-366

M8529
AbMole BioScience
CAS Number1527503-11-2
Product group Chemicals
Molecular Weight329.44
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Overview

  • Supplier
    AbMole BioScience
  • Product Name
    A-366
  • Delivery Days Customer
    9
  • CAS Number
    1527503-11-2
  • Category Supplier
    Chemical
  • Certification
    Research Use Only
  • Molecular Formula
    C19H27N3O2
  • Molecular Weight
    329.44
  • Scientific Description
    A-366 is a potent and highly selective peptide-competitive inhibitor of histone methyltransferase G9a, with IC50s of 3.3 nM and 38 nM for G9a and GLP, respectively, and is more than 1,000-fold selective for G9a and GLP over 21 other methyltransferases. A-366 is also a potent inhibitor of Spindlin1-H3K4me3 interaction (IC50=182.6 nM).A-366 shows high affinity for human H3R (Ki=17 nM) and exhibits subtype selectivity between subpopulations of the histaminergic and dopaminergic receptor families. It can be used for induction and maintenance of pluripotent stem cells in mice.
  • SMILES
    COC1=C(OCCCN2CCCC2)C=C3N=C(N)C4(CCC4)C3=C1
  • UNSPSC
    12352200

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