ACBI1

Biorbyt

ACBI1 [2375564-55-7]

10

2375564-55-7

Research Use Only

C49H58FN9O7S

936.1043

ACBI1 is a potent and cooperative PROTAC degrader of SMARCA2, SMARCA4 and PBRM1 with DC50 of 6 nM, 11 nM and 32 nM for SMARCA2, SMARCA4 and PBRM1 in MV-4-11 cells, respectively. ACBI1 is composed of a bromodomain ligand, a linker, and the E3 ubiquitin ligase VHL. ACBI1 induces anti-proliferative effects and apoptosis.

S1C([H])=NC(C([H])([H])[H])=C1C1C([H])=C([H])C(=C(C=1[H])OC([H])([H])C([H])([H])OC1C([H])=C([H])C(=C([H])C=1[H])C([H])([H])N1C([H])([H])C([H])([H])N(C2C(N([H])[H])=NN=C(C3=C([H])C([H])=C([H])C([H])=C3O[H])C=2[H])C([H])([H])C1([H])[H])C([H])([H])N([H])C([C@]1([H])C([H])([H])[C@]([H])(C([H])([H])N1C([C@]([H])(C(C([H])([H])[H])(C([H])([H])[H])C([H])([H])[H])N([H])C(C1(C([H])([H])C1([H])[H])F)=O)=O)O[H])=O

12352200