IHC-P analysis of human kidney tissue section using GTX01160 ACE2 antibody [SN0754].
![Human tissue extract (30 microg) was separated by 7.5% SDS-PAGE, and the membrane was blotted with ACE2 antibody [SN0754] (GTX01160) diluted at 1:500. The HRP-conjugated anti-rabbit IgG antibody (GTX213110-01) was used to detect the primary antibody.](https://www.genetex.com/upload/website/prouct_img/normal/GTX01160/GTX01160_HK0921_20200228_WB__kidney_w_23053121_752.webp "Human tissue extract (30 microg) was separated by 7.5% SDS-PAGE, and the membrane was blotted with ACE2 antibody [SN0754] (GTX01160) diluted at 1:500. The HRP-conjugated anti-rabbit IgG antibody (GTX213110-01) was used to detect the primary antibody.")
![ACE2 antibody [SN0754] detects ACE2 protein at cell membrane by immunohistochemical analysis. Sample: Paraffin-embedded human kidney. ACE2 stained by ACE2 antibody [SN0754] (GTX01160) diluted at 1:500. Antigen Retrieval: Citrate buffer, pH 6.0, 15 min](https://www.genetex.com/upload/website/prouct_img/normal/GTX01160/GTX01160_HK0921_20200313_IHC-P_1_w_23053121_372.webp "ACE2 antibody [SN0754] detects ACE2 protein at cell membrane by immunohistochemical analysis. Sample: Paraffin-embedded human kidney. ACE2 stained by ACE2 antibody [SN0754] (GTX01160) diluted at 1:500. Antigen Retrieval: Citrate buffer, pH 6.0, 15 min")
![ACE2 antibody [SN0754] detects ACE2 protein at cell membrane by immunohistochemical analysis. Sample: Paraffin-embedded human kidney. ACE2 stained by ACE2 antibody [SN0754] (GTX01160) diluted at 1:2000. Antigen Retrieval: Citrate buffer, pH 6.0, 15 min](https://www.genetex.com/upload/website/prouct_img/normal/GTX01160/GTX01160_HK0921_20200313_IHC-P_2_w_23053121_729.webp "ACE2 antibody [SN0754] detects ACE2 protein at cell membrane by immunohistochemical analysis. Sample: Paraffin-embedded human kidney. ACE2 stained by ACE2 antibody [SN0754] (GTX01160) diluted at 1:2000. Antigen Retrieval: Citrate buffer, pH 6.0, 15 min")
![ACE2 antibody [SN0754] detects ACE2 protein at cell membrane by immunohistochemical analysis. Sample: Paraffin-embedded human intestine. ACE2 stained by ACE2 antibody [SN0754] (GTX01160) diluted at 1:2000. Antigen Retrieval: Citrate buffer, pH 6.0, 15 min](https://www.genetex.com/upload/website/prouct_img/normal/GTX01160/GTX01160_HK0921_20200313_IHC-P_3_w_23053121_699.webp "ACE2 antibody [SN0754] detects ACE2 protein at cell membrane by immunohistochemical analysis. Sample: Paraffin-embedded human intestine. ACE2 stained by ACE2 antibody [SN0754] (GTX01160) diluted at 1:2000. Antigen Retrieval: Citrate buffer, pH 6.0, 15 min")
![ACE2 antibody [SN0754] detects ACE2 protein at cell membrane by immunohistochemical analysis. Sample: Paraffin-embedded mouse kidney. ACE2 stained by ACE2 antibody [SN0754] (GTX01160) diluted at 1:2000. Antigen Retrieval: Citrate buffer, pH 6.0, 15 min](https://www.genetex.com/upload/website/prouct_img/normal/GTX01160/GTX01160_HK0921_20200313_IHC-P_M_w_23053121_166.webp "ACE2 antibody [SN0754] detects ACE2 protein at cell membrane by immunohistochemical analysis. Sample: Paraffin-embedded mouse kidney. ACE2 stained by ACE2 antibody [SN0754] (GTX01160) diluted at 1:2000. Antigen Retrieval: Citrate buffer, pH 6.0, 15 min")
IHC-P analysis of human kidney tissue section using GTX01160 ACE2 antibody [SN0754].
ACE2 antibody [SN0754]
GTX01160
ApplicationsImmunoFluorescence, Western Blot, ImmunoCytoChemistry, ImmunoHistoChemistry, ImmunoHistoChemistry Paraffin
Product group Antibodies
ReactivityHuman, Monkey, Mouse, Rat
TargetACE2
Overview
- SupplierGeneTex
- Product NameACE2 antibody [SN0754]
- Delivery Days Customer9
- Application Supplier NoteWB: 1:500~1:5000. ICC/IF: 1:100-1:500. IHC-P: 1:50-1:200. *Optimal dilutions/concentrations should be determined by the researcher.Not tested in other applications.
- ApplicationsImmunoFluorescence, Western Blot, ImmunoCytoChemistry, ImmunoHistoChemistry, ImmunoHistoChemistry Paraffin
- CertificationResearch Use Only
- ClonalityMonoclonal
- Clone IDSN0754
- Concentration1 mg/ml
- ConjugateUnconjugated
- Gene ID59272
- Target nameACE2
- Target descriptionangiotensin converting enzyme 2
- Target synonymsACEH, angiotensin-converting enzyme 2, ACE-related carboxypeptidase, angiotensin I converting enzyme (peptidyl-dipeptidase A) 2, angiotensin I converting enzyme 2, angiotensin-converting enzyme homolog, angiotensin-converting enzyme-related carboxypeptidase, metalloprotease MPROT15, peptidyl-dipeptidase A
- HostRabbit
- IsotypeIgG
- Protein IDQ9BYF1
- Protein NameAngiotensin-converting enzyme 2
- Scientific DescriptionThe protein encoded by this gene belongs to the angiotensin-converting enzyme family of dipeptidyl carboxydipeptidases and has considerable homology to human angiotensin 1 converting enzyme. This secreted protein catalyzes the cleavage of angiotensin I into angiotensin 1-9, and angiotensin II into the vasodilator angiotensin 1-7. The organ- and cell-specific expression of this gene suggests that it may play a role in the regulation of cardiovascular and renal function, as well as fertility. In addition, the encoded protein is a functional receptor for the spike glycoprotein of the human coronaviruses SARS and HCoV-NL63. [provided by RefSeq, Jul 2008]
- ReactivityHuman, Monkey, Mouse, Rat
- Storage Instruction-20°C or -80°C,2°C to 8°C
- UNSPSC12352203
References
- Yang CF, Liao CC, Hsu HW, et al. Human ACE2 protein is a molecular switch controlling the mode of SARS-CoV-2 transmission. J Biomed Sci. 2023,30(1):87. doi: 10.1186/s12929-023-00980-wRead this paper
- Lee CY, Nguyen AT, Doan LH, et al. Repurposing Astragalus Polysaccharide PG2 for Inhibiting ACE2 and SARS-CoV-2 Spike Syncytial Formation and Anti-Inflammatory Effects. Viruses. 2023,15(3). doi: 10.3390/v15030641Read this paper
- Lu Y, Zhu Q, Fox DM, et al. SARS-CoV-2 down-regulates ACE2 through lysosomal degradation. Mol Biol Cell. 2022,33(14):ar147. doi: 10.1091/mbc.E22-02-0045Read this paper
- Sherman EJ, Mirabelli C, Tang VT, et al. Identification of cell type specific ACE2 modifiers by CRISPR screening. PLoS Pathog. 2022,18(3):e1010377. doi: 10.1371/journal.ppat.1010377Read this paper
- Generali M, Kehl D, Wanner D, et al. Heterogeneous expression of ACE2 and TMPRRS2 in mesenchymal stromal cells. J Cell Mol Med. 2022,26(1):228-234. doi: 10.1111/jcmm.17048Read this paper
- Lee CY, Huang CH, Rastegari E, et al. Tumor Necrosis Factor-Alpha Exacerbates Viral Entry in SARS-CoV2-Infected iPSC-Derived Cardiomyocytes. Int J Mol Sci. 2021,22(18). doi: 10.3390/ijms22189869Read this paper
- Wang HI, Chuang ZS, Kao YT, et al. Small Structural Proteins E and M Render the SARS-CoV-2 Pseudovirus More Infectious and Reveal the Phenotype of Natural Viral Variants. Int J Mol Sci. 2021,22(16). doi: 10.3390/ijms22169087Read this paper
- Sherman EJ, Emmer BT. ACE2 protein expression within isogenic cell lines is heterogeneous and associated with distinct transcriptomes. Sci Rep. 2021,11(1):15900. doi: 10.1038/s41598-021-95308-9Read this paper
- Hsieh MH, Beirag N, Murugaiah V, et al. Human Surfactant Protein D Binds Spike Protein and Acts as an Entry Inhibitor of SARS-CoV-2 Pseudotyped Viral Particles. Front Immunol. 2021,12:641360. doi: 10.3389/fimmu.2021.641360Read this paper
- Ahmad Mulyadi Lai HI, Chou SJ, Chien Y, et al. Expression of Endogenous Angiotensin-Converting Enzyme 2 in Human Induced Pluripotent Stem Cell-Derived Retinal Organoids. Int J Mol Sci. 2021,22(3). doi: 10.3390/ijms22031320Read this paper
Datasheet
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