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IHC-P analysis of formalin fixed human lung cancer tissue section using GTX54920 Aggrecan antibody. Antigen retrieval : Heat mediated antigen retrieval with sodium citrate buffer (pH 6.0)

Aggrecan antibody

GTX54920

ApplicationsImmunoFluorescence, Western Blot, ImmunoCytoChemistry, ImmunoHistoChemistry, ImmunoHistoChemistry Paraffin

Product group Antibodies

ReactivityHuman, Mouse, Porcine, Rat

TargetACAN

Overview

Supplier
GeneTex
Product Name
Aggrecan antibody
Delivery Days Customer
9
Application Supplier Note
WB: 1:500 - 1:1000. IHC-P: 1:100 - 1:200. *Optimal dilutions/concentrations should be determined by the researcher.Not tested in other applications.
Applications
ImmunoFluorescence, Western Blot, ImmunoCytoChemistry, ImmunoHistoChemistry, ImmunoHistoChemistry Paraffin
Certification
Research Use Only
Clonality
Polyclonal
Conjugate
Unconjugated
Gene ID176
Target name
ACAN
Target description
aggrecan
Target synonyms
AGC1, AGCAN, CSPG1, CSPGCP, MSK16, SEDK, SSOAOD, aggrecan core protein, cartilage-specific proteoglycan core protein, chondroitin sulfate proteoglycan core protein 1, large aggregating proteoglycan
Host
Rabbit
Isotype
IgG
Protein IDP16112
Protein Name
Aggrecan core protein
Scientific Description
This gene is a member of the aggrecan/versican proteoglycan family. The encoded protein is an integral part of the extracellular matrix in cartilagenous tissue and it withstands compression in cartilage. Mutations in this gene may be involved in skeletal dysplasia and spinal degeneration. Multiple alternatively spliced transcript variants that encode different protein isoforms have been observed in this gene. [provided by RefSeq, Jul 2008]
Reactivity
Human, Mouse, Porcine, Rat
Storage Instruction
-20°C or -80°C,2°C to 8°C
UNSPSC
12352203

References

Csukasi F, Bosakova M, Barta T, et al. Skeletal diseases caused by mutations in PTH1R show aberrant differentiation of skeletal progenitors due to dysregulation of DEPTOR. Front Cell Dev Biol. 2022,10:963389. doi: 10.3389/fcell.2022.963389
Read this paper
Ping SH, Tian FM, Zhao ZM, et al. Protective effects of equol on the cartilage and subchondral bone in ovariectomized rats with osteoarthritis. Iran J Basic Med Sci. 2022,25(10):1228-1233. doi: 10.22038/IJBMS.2022.59036.13115
Read this paper
Sun Q, Tian FM, Liu F, et al. Denosumab alleviates intervertebral disc degeneration adjacent to lumbar fusion by inhibiting endplate osteochondral remodeling and vertebral osteoporosis in ovariectomized rats. Arthritis Res Ther. 2021,23(1):152. doi: 10.1186/s13075-021-02525-8
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Lee SS, Wu YC, Huang SH, et al. A novel 3D histotypic cartilage construct engineered by supercritical carbon dioxide decellularized porcine nasal cartilage graft and chondrocytes exhibited chondrogenic capability in vitro. Int J Med Sci. 2021,18(10):2217-2227. doi: 10.7150/ijms.56342
Read this paper
Chen CY, Li C, Ke CJ, et al. Kartogenin Enhances Chondrogenic Differentiation of MSCs in 3D Tri-Copolymer Scaffolds and the Self-Designed Bioreactor System. Biomolecules. 2021,11(1). doi: 10.3390/biom11010115
Read this paper
Ping SH, Tian FM, Liu H, et al. Raloxifene inhibits the overexpression of TGF-β1 in cartilage and regulates the metabolism of subchondral bone in rats with osteoporotic osteoarthritis. Bosn J Basic Med Sci. 2021,21(3):284-293. doi: 10.17305/bjbms.2020.5142
Read this paper
Chen YT, Lee HS, Hsieh DJ, et al. 3D composite engineered using supercritical CO(2) decellularized porcine cartilage scaffold, chondrocytes, and PRP: Role in articular cartilage regeneration. J Tissue Eng Regen Med. 2021,15(2):163-175. doi: 10.1002/term.3162
Read this paper
Shao LT, Gou Y, Fang JK, et al. Parathyroid hormone (1-34) ameliorates cartilage degeneration and subchondral bone deterioration in collagenase-induced osteoarthritis model in mice. Bone Joint Res. 2020,9(10):675-688. doi: 10.1302/2046-3758.910.BJR-2020-0018.R1
Read this paper
Zhang L, Qi M, Chen J, et al. Impaired autophagy triggered by HDAC9 in mesenchymal stem cells accelerates bone mass loss. Stem Cell Res Ther. 2020,11(1):269. doi: 10.1186/s13287-020-01785-6
Read this paper
Muhammad SA, Nordin N, Hussin P, et al. Optimization of Protocol for Isolation of Chondrocytes from Human Articular Cartilage. Cartilage. 2021,13(2_suppl):872S-884S. doi: 10.1177/1947603519876333
Read this paper

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Aggrecan antibody

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