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WB analysis of various tissue lysates using GTX54920 Aggrecan antibody. (A): CT26 (B): C6 (C): Hela

Aggrecan antibody

GTX54920

ApplicationsImmunoFluorescence, Western Blot, ImmunoCytoChemistry, ImmunoHistoChemistry, ImmunoHistoChemistry Paraffin

Product group Antibodies

ReactivityHuman, Mouse, Porcine, Rat

TargetACAN

Overview

Supplier
GeneTex
Product Name
Aggrecan antibody
Delivery Days Customer
9
Application Supplier Note
WB: 1:500 - 1:1000. IHC-P: 1:100 - 1:200. *Optimal dilutions/concentrations should be determined by the researcher.Not tested in other applications.
Applications
ImmunoFluorescence, Western Blot, ImmunoCytoChemistry, ImmunoHistoChemistry, ImmunoHistoChemistry Paraffin
Certification
Research Use Only
Clonality
Polyclonal
Conjugate
Unconjugated
Gene ID176
Target name
ACAN
Target description
aggrecan
Target synonyms
AGC1, AGCAN, CSPG1, CSPGCP, MSK16, SEDK, SSOAOD, aggrecan core protein, cartilage-specific proteoglycan core protein, chondroitin sulfate proteoglycan core protein 1, large aggregating proteoglycan
Host
Rabbit
Isotype
IgG
Protein IDP16112
Protein Name
Aggrecan core protein
Scientific Description
This gene is a member of the aggrecan/versican proteoglycan family. The encoded protein is an integral part of the extracellular matrix in cartilagenous tissue and it withstands compression in cartilage. Mutations in this gene may be involved in skeletal dysplasia and spinal degeneration. Multiple alternatively spliced transcript variants that encode different protein isoforms have been observed in this gene. [provided by RefSeq, Jul 2008]
Reactivity
Human, Mouse, Porcine, Rat
Storage Instruction
-20°C or -80°C,2°C to 8°C
UNSPSC
41116161

References

Parathyroid hormone (1-34) retards the lumbar facet joint degeneration and activates Wnt/beta-catenin signaling pathway in ovariectomized rats.
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Skeletal diseases caused by mutations in PTH1R show aberrant differentiation of skeletal progenitors due to dysregulation of DEPTOR.
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Protective effects of equol on the cartilage and subchondral bone in ovariectomized rats with osteoarthritis.
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Denosumab alleviates intervertebral disc degeneration adjacent to lumbar fusion by inhibiting endplate osteochondral remodeling and vertebral osteoporosis in ovariectomized rats. Sun Q et al., 2021 May 28, Arthritis Res Ther
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A novel 3D histotypic cartilage construct engineered by supercritical carbon dioxide decellularized porcine nasal cartilage graft and chondrocytes exhibited chondrogenic capability in vitro. Lee SS et al., 2021, Int J Med Sci
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Kartogenin Enhances Chondrogenic Differentiation of MSCs in 3D Tri-Copolymer Scaffolds and the Self-Designed Bioreactor System. Chen CY et al., 2021 Jan 16, Biomolecules
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Raloxifene inhibits the overexpression of TGF-beta1 in cartilage and regulates the metabolism of subchondral bone in rats with osteoporotic osteoarthritis. Ping SH et al., 2021 Jun 1, Bosn J Basic Med Sci
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3D composite engineered using supercritical CO2 decellularized porcine cartilage scaffold, chondrocytes, and PRP: Role in articular cartilage regeneration. Chen YT et al., 2021 Feb, J Tissue Eng Regen Med
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Parathyroid hormone (1-34) ameliorates cartilage degeneration and subchondral bone deterioration in collagenase-induced osteoarthritis model in mice. Shao LT et al., 2020 Oct, Bone Joint Res
Read this paper

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Aggrecan antibody

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Overview

References

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