
WB analysis of mouse liver lysate using GTX89149 AGTR1 antibody, Internal. Dilution : 0.3μg/ml Loading : 35μg protein in RIPA buffer
AGTR1 antibody, Internal
GTX89149
ApplicationsWestern Blot
Product group Antibodies
ReactivityHuman, Mouse
TargetAGTR1
Overview
- SupplierGeneTex
- Product NameAGTR1 antibody, Internal
- Delivery Days Customer9
- Application Supplier NoteWB: 0.3-1microg/ml. *Optimal dilutions/concentrations should be determined by the researcher.Not tested in other applications.
- ApplicationsWestern Blot
- CertificationResearch Use Only
- ClonalityPolyclonal
- Concentration0.50 mg/ml
- ConjugateUnconjugated
- Gene ID185
- Target nameAGTR1
- Target descriptionangiotensin II receptor type 1
- Target synonymsAG2S, AGTR1B, AT1, AT1AR, AT1B, AT1BR, AT1R, AT2R1, ATR1, HAT1R, type-1 angiotensin II receptor, AT1 receptor, type-1B angiotensin II receptor
- HostGoat
- IsotypeIgG
- Protein IDP30556
- Protein NameType-1 angiotensin II receptor
- Scientific DescriptionAngiotensin II is a potent vasopressor hormone and a primary regulator of aldosterone secretion. It is an important effector controlling blood pressure and volume in the cardiovascular system. It acts through at least two types of receptors. This gene encodes the type 1 receptor which is thought to mediate the major cardiovascular effects of angiotensin II. This gene may play a role in the generation of reperfusion arrhythmias following restoration of blood flow to ischemic or infarcted myocardium. It was previously thought that a related gene, denoted as AGTR1B, existed; however, it is now believed that there is only one type 1 receptor gene in humans. Multiple alternatively spliced transcript variants have been reported for this gene. [provided by RefSeq, Jul 2012]
- ReactivityHuman, Mouse
- Storage Instruction-20°C or -80°C,2°C to 8°C
- UNSPSC12352203
References
- Nemoto T, Nakakura T, Kakinuma Y. Elevated blood pressure in high-fat diet-exposed low birthweight rat offspring is most likely caused by elevated glucocorticoid levels due to abnormal pituitary negative feedback. PLoS One. 2020,15(8):e0238223. doi: 10.1371/journal.pone.0238223Read this paper
- Sun Y, Li Y, Wang M, et al. Increased AT(2)R expression is induced by AT(1)R autoantibody via two axes, Klf-5/IRF-1 and circErbB4/miR-29a-5p, to promote VSMC migration. Cell Death Dis. 2020,11(6):432. doi: 10.1038/s41419-020-2643-5Read this paper






![AGTR1 antibody [HL2524] detects AGTR1 protein at cell membrane and cytoplasm by immunohistochemical analysis. Sample: Paraffin-embedded Huh-7 xenograft. AGTR1 stained by AGTR1 antibody [HL2524] (GTX638885) diluted at 1:100. Antigen Retrieval: Citrate buffer, pH 6.0, 15 min](https://www.genetex.com/upload/website/prouct_img/normal/GTX638885/GTX638885_T-45117_20230829_IHC-P_23091319_854.webp)
![Huh-7 cytoplasma extracts and membrane extracts (30 μg) were separated by 10% SDS-PAGE, and the membrane was blotted with AGTR1 antibody [HL2526] (GTX638887) diluted at 1:500. The HRP-conjugated anti-rabbit IgG antibody (GTX213110-01) was used to detect the primary antibody, and the signal was developed with Trident ECL plus-Enhanced. (CE: cytoplasma extract; ME: membrane extract)](https://www.genetex.com/upload/website/prouct_img/normal/GTX638887/GTX638887_T-45117_20230825_WB_Fraction_23083020_453.webp)