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AKR1C1 antibody

GTX105620
GeneTex
ApplicationsImmunoFluorescence, Western Blot, ImmunoCytoChemistry, ImmunoHistoChemistry, ImmunoHistoChemistry Paraffin
Product group Antibodies
TargetAKR1C1
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Overview

  • Supplier
    GeneTex
  • Product Name
    AKR1C1 antibody
  • Delivery Days Customer
    9
  • Application Supplier Note
    WB: 1:500-1:3000. ICC/IF: 1:100-1:1000. IHC-P: 1:100-1:1000. *Optimal dilutions/concentrations should be determined by the researcher.Not tested in other applications.
  • Applications
    ImmunoFluorescence, Western Blot, ImmunoCytoChemistry, ImmunoHistoChemistry, ImmunoHistoChemistry Paraffin
  • Certification
    Research Use Only
  • Clonality
    Polyclonal
  • Concentration
    0.6 mg/ml
  • Conjugate
    Unconjugated
  • Gene ID1645
  • Target name
    AKR1C1
  • Target description
    aldo-keto reductase family 1 member C1
  • Target synonyms
    20 alpha-hydroxysteroid dehydrogenase; 20-ALPHA-HSD; 2-ALPHA-HSD; aldo-keto reductase C; aldo-keto reductase family 1 member C1; C9; chlordecone reductase homolog HAKRC; DD1; DD1/DD2; DDH; DDH1; dihydrodiol dehydrogenase 1; dihydrodiol dehydrogenase 1/2; dihydrodiol dehydrogenase 1; 20-alpha (3-alpha)-hydroxysteroid dehydrogenase; H-37; HAKRC; HBAB; hepatic dihydrodiol dehydrogenase; high-affinity hepatic bile acid-binding protein; indanol dehydrogenase; MBAB; trans-1,2-dihydrobenzene-1,2-diol dehydrogenase; type II 3-alpha-hydroxysteroid dehydrogenase
  • Host
    Rabbit
  • Isotype
    IgG
  • Protein IDQ04828
  • Protein Name
    Aldo-keto reductase family 1 member C1
  • Scientific Description
    This gene encodes a member of the aldo/keto reductase superfamily, which consists of more than 40 known enzymes and proteins. These enzymes catalyze the conversion of aldehydes and ketones to their corresponding alcohols by utilizing NADH and/or NADPH as cofactors. The enzymes display overlapping but distinct substrate specificity. This enzyme catalyzes the reaction of progesterone to the inactive form 20-alpha-hydroxy-progesterone. This gene shares high sequence identity with three other gene members and is clustered with those three genes at chromosome 10p15-p14. [provided by RefSeq]
  • Storage Instruction
    -20°C or -80°C,2°C to 8°C
  • UNSPSC
    12352203

References

  • 20alpha-Hydroxysteroid Dehydrogenase Expression in the Human Myometrium at Term and Preterm Birth: Relationships to Fetal Sex and Maternal Body Mass Index.
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  • AKR1C1 promotes non-small cell lung cancer proliferation via crosstalk between HIF-1alpha and metabolic reprogramming. Chang LL et al., 2022 Jun, Transl Oncol
    Read more
  • Pro-inflammatory signals induce 20alpha-HSD expression in myometrial cells: A key mechanism for local progesterone withdrawal. Nadeem L et al., 2021 Jul, J Cell Mol Med
    Read more
  • Upregulation of lipid metabolism genes in the breast prior to cancer diagnosis. Marino N et al., 2020, NPJ Breast Cancer
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  • The SIRT2-mediated deacetylation of AKR1C1 is required for suppressing its pro-metastasis function in Non-Small Cell Lung Cancer. Zhu H et al., 2020, Theranostics
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  • Upregulation of AKR1C1 in mesenchymal stromal cells promotes the survival of acute myeloid leukaemia cells. Jiang Y et al., 2020 May, Br J Haematol
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  • Liquiritin, as a Natural Inhibitor of AKR1C1, Could Interfere With the Progesterone Metabolism. Zeng C et al., 2019, Front Physiol
    Read more
  • AKR1C1 Activates STAT3 to Promote the Metastasis of Non-Small Cell Lung Cancer. Zhu H et al., 2018, Theranostics
    Read more
  • AgRP-Expressing Adrenal Chromaffin Cells Are Involved in the Sympathetic Response to Fasting. Gupta R et al., 2017 Aug 1, Endocrinology
    Read more
  • Preferential expression of potential markers for cancer stem cells in large cell neuroendocrine carcinoma of the lung. An FFPE proteomic study. Nomura M et al., 2011 Sep 3, J Clin Bioinforma
    Read more

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