AKR1C1 antibody
GTX105620
ApplicationsImmunoFluorescence, Western Blot, ImmunoCytoChemistry, ImmunoHistoChemistry, ImmunoHistoChemistry Paraffin
Product group Antibodies
ReactivityHuman, Mouse
TargetAKR1C1
Overview
- SupplierGeneTex
- Product NameAKR1C1 antibody
- Delivery Days Customer9
- Antibody SpecificityBased on sequence homology, this antibody may cross react with AKR1C2, AKR1C3, or AKR1C4 protein.
- Application Supplier NoteWB: 1:500-1:3000. ICC/IF: 1:100-1:1000. IHC-P: 1:100-1:1000. *Optimal dilutions/concentrations should be determined by the researcher.Not tested in other applications.
- ApplicationsImmunoFluorescence, Western Blot, ImmunoCytoChemistry, ImmunoHistoChemistry, ImmunoHistoChemistry Paraffin
- CertificationResearch Use Only
- ClonalityPolyclonal
- Concentration0.6 mg/ml
- ConjugateUnconjugated
- Gene ID1645
- Target nameAKR1C1
- Target descriptionaldo-keto reductase family 1 member C1
- Target synonyms20 alpha-hydroxysteroid dehydrogenase; 20-ALPHA-HSD; 2-ALPHA-HSD; aldo-keto reductase C; aldo-keto reductase family 1 member C1; C9; chlordecone reductase homolog HAKRC; DD1; DD1/DD2; DDH; DDH1; dihydrodiol dehydrogenase 1; dihydrodiol dehydrogenase 1/2; dihydrodiol dehydrogenase 1; 20-alpha (3-alpha)-hydroxysteroid dehydrogenase; H-37; HAKRC; HBAB; hepatic dihydrodiol dehydrogenase; high-affinity hepatic bile acid-binding protein; indanol dehydrogenase; MBAB; trans-1,2-dihydrobenzene-1,2-diol dehydrogenase; type II 3-alpha-hydroxysteroid dehydrogenase
- HostRabbit
- IsotypeIgG
- Protein IDQ04828
- Protein NameAldo-keto reductase family 1 member C1
- Scientific DescriptionThis gene encodes a member of the aldo/keto reductase superfamily, which consists of more than 40 known enzymes and proteins. These enzymes catalyze the conversion of aldehydes and ketones to their corresponding alcohols by utilizing NADH and/or NADPH as cofactors. The enzymes display overlapping but distinct substrate specificity. This enzyme catalyzes the reaction of progesterone to the inactive form 20-alpha-hydroxy-progesterone. This gene shares high sequence identity with three other gene members and is clustered with those three genes at chromosome 10p15-p14. [provided by RefSeq]
- ReactivityHuman, Mouse
- Storage Instruction-20°C or -80°C,2°C to 8°C
- UNSPSC12352203
References
- 20alpha-Hydroxysteroid Dehydrogenase Expression in the Human Myometrium at Term and Preterm Birth: Relationships to Fetal Sex and Maternal Body Mass Index.Read more
- AKR1C1 promotes non-small cell lung cancer proliferation via crosstalk between HIF-1alpha and metabolic reprogramming. Chang LL et al., 2022 Jun, Transl OncolRead more
- Pro-inflammatory signals induce 20alpha-HSD expression in myometrial cells: A key mechanism for local progesterone withdrawal. Nadeem L et al., 2021 Jul, J Cell Mol MedRead more
- Upregulation of lipid metabolism genes in the breast prior to cancer diagnosis. Marino N et al., 2020, NPJ Breast CancerRead more
- The SIRT2-mediated deacetylation of AKR1C1 is required for suppressing its pro-metastasis function in Non-Small Cell Lung Cancer. Zhu H et al., 2020, TheranosticsRead more
- Upregulation of AKR1C1 in mesenchymal stromal cells promotes the survival of acute myeloid leukaemia cells. Jiang Y et al., 2020 May, Br J HaematolRead more
- Liquiritin, as a Natural Inhibitor of AKR1C1, Could Interfere With the Progesterone Metabolism. Zeng C et al., 2019, Front PhysiolRead more
- AKR1C1 Activates STAT3 to Promote the Metastasis of Non-Small Cell Lung Cancer. Zhu H et al., 2018, TheranosticsRead more
- AgRP-Expressing Adrenal Chromaffin Cells Are Involved in the Sympathetic Response to Fasting. Gupta R et al., 2017 Aug 1, EndocrinologyRead more
- Preferential expression of potential markers for cancer stem cells in large cell neuroendocrine carcinoma of the lung. An FFPE proteomic study. Nomura M et al., 2011 Sep 3, J Clin BioinformaRead more