AKR1C1 antibody
GTX105620
ApplicationsImmunoFluorescence, Western Blot, ImmunoCytoChemistry, ImmunoHistoChemistry, ImmunoHistoChemistry Paraffin
Product group Antibodies
ReactivityHuman, Mouse
TargetAKR1C1
Overview
- SupplierGeneTex
- Product NameAKR1C1 antibody
- Delivery Days Customer9
- Application Supplier NoteWB: 1:500-1:3000. ICC/IF: 1:100-1:1000. IHC-P: 1:100-1:1000. *Optimal dilutions/concentrations should be determined by the researcher.Not tested in other applications.
- ApplicationsImmunoFluorescence, Western Blot, ImmunoCytoChemistry, ImmunoHistoChemistry, ImmunoHistoChemistry Paraffin
- CertificationResearch Use Only
- ClonalityPolyclonal
- Concentration0.6 mg/ml
- ConjugateUnconjugated
- Gene ID1645
- Target nameAKR1C1
- Target descriptionaldo-keto reductase family 1 member C1
- Target synonyms2-ALPHA-HSD, 20-ALPHA-HSD, C9, DD1, DD1/DD2, DDH, DDH1, H-37, HAKRC, HBAB, MBAB, aldo-keto reductase family 1 member C1, 20 alpha-hydroxysteroid dehydrogenase, aldo-keto reductase C, chlordecone reductase homolog HAKRC, dihydrodiol dehydrogenase 1, dihydrodiol dehydrogenase 1/2, dihydrodiol dehydrogenase 1; 20-alpha (3-alpha)-hydroxysteroid dehydrogenase, hepatic dihydrodiol dehydrogenase, high-affinity hepatic bile acid-binding protein, indanol dehydrogenase, trans-1,2-dihydrobenzene-1,2-diol dehydrogenase, type II 3-alpha-hydroxysteroid dehydrogenase
- HostRabbit
- IsotypeIgG
- Protein IDQ04828
- Protein NameAldo-keto reductase family 1 member C1
- Scientific DescriptionThis gene encodes a member of the aldo/keto reductase superfamily, which consists of more than 40 known enzymes and proteins. These enzymes catalyze the conversion of aldehydes and ketones to their corresponding alcohols by utilizing NADH and/or NADPH as cofactors. The enzymes display overlapping but distinct substrate specificity. This enzyme catalyzes the reaction of progesterone to the inactive form 20-alpha-hydroxy-progesterone. This gene shares high sequence identity with three other gene members and is clustered with those three genes at chromosome 10p15-p14. [provided by RefSeq]
- ReactivityHuman, Mouse
- Storage Instruction-20°C or -80°C,2°C to 8°C
- UNSPSC12352203
References
- Paul M, Zakar T, Phung J, et al. 20α-Hydroxysteroid Dehydrogenase Expression in the Human Myometrium at Term and Preterm Birth: Relationships to Fetal Sex and Maternal Body Mass Index. Reprod Sci. 2023,30(8):2512-2523. doi: 10.1007/s43032-023-01183-2Read this paper
- Chang LL, Lu PH, Yang W, et al. AKR1C1 promotes non-small cell lung cancer proliferation via crosstalk between HIF-1α and metabolic reprogramming. Transl Oncol. 2022,20:101421. doi: 10.1016/j.tranon.2022.101421Read this paper
- Nadeem L, Balendran R, Dorogin A, et al. Pro-inflammatory signals induce 20α-HSD expression in myometrial cells: A key mechanism for local progesterone withdrawal. J Cell Mol Med. 2021,25(14):6773-6785. doi: 10.1111/jcmm.16681Read this paper
- Marino N, German R, Rao X, et al. Upregulation of lipid metabolism genes in the breast prior to cancer diagnosis. NPJ Breast Cancer. 2020,6:50. doi: 10.1038/s41523-020-00191-8Read this paper
- Zhu H, Hu Y, Zeng C, et al. The SIRT2-mediated deacetylation of AKR1C1 is required for suppressing its pro-metastasis function in Non-Small Cell Lung Cancer. Theranostics. 2020,10(5):2188-2200. doi: 10.7150/thno.39151Read this paper
- Jiang Y, Li Y, Cheng J, et al. Upregulation of AKR1C1 in mesenchymal stromal cells promotes the survival of acute myeloid leukaemia cells. Br J Haematol. 2020,189(4):694-706. doi: 10.1111/bjh.16253Read this paper
- Zeng C, Zhu D, You J, et al. Liquiritin, as a Natural Inhibitor of AKR1C1, Could Interfere With the Progesterone Metabolism. Front Physiol. 2019,10:833. doi: 10.3389/fphys.2019.00833Read this paper
- Zhu H, Chang LL, Yan FJ, et al. AKR1C1 Activates STAT3 to Promote the Metastasis of Non-Small Cell Lung Cancer. Theranostics. 2018,8(3):676-692. doi: 10.7150/thno.21463Read this paper
- Gupta R, Ma Y, Wang M, et al. AgRP-Expressing Adrenal Chromaffin Cells Are Involved in the Sympathetic Response to Fasting. Endocrinology. 2017,158(8):2572-2584. doi: 10.1210/en.2016-1268Read this paper
- Nomura M, Fukuda T, Fujii K, et al. Preferential expression of potential markers for cancer stem cells in large cell neuroendocrine carcinoma of the lung. An FFPE proteomic study. J Clin Bioinforma. 2011,1(1):23. doi: 10.1186/2043-9113-1-23Read this paper
Datasheet
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