ProductsBack/alpha 2 Macroglobulin antibody

WB analysis of various sample lysates using GTX32434 alpha 2 Macroglobulin antibody. Dilution : 1:500 Loading : 25microg per lane

alpha 2 Macroglobulin antibody

GTX32434

ApplicationsImmunoFluorescence, Western Blot, ImmunoCytoChemistry

Product group Antibodies

ReactivityHuman, Mouse, Rat

TargetA2M

Overview

Supplier
GeneTex
Product Name
alpha 2 Macroglobulin antibody
Delivery Days Customer
9
Application Supplier Note
WB: 1:500 - 1:2000. ICC/IF: 1:50 - 1:200. *Optimal dilutions/concentrations should be determined by the researcher.Not tested in other applications.
Applications
ImmunoFluorescence, Western Blot, ImmunoCytoChemistry
Certification
Research Use Only
Clonality
Polyclonal
Conjugate
Unconjugated
Gene ID2
Target name
A2M
Target description
alpha-2-macroglobulin
Target synonyms
A2MD; alpha-2-M; alpha-2-macroglobulin; C3 and PZP-like alpha-2-macroglobulin domain-containing protein 5; CPAMD5; FWP007; S863-7
Host
Rabbit
Isotype
IgG
Protein IDP01023
Protein Name
Alpha-2-macroglobulin
Scientific Description
The protein encoded by this gene is a protease inhibitor and cytokine transporter. It uses a bait-and-trap mechanism to inhibit a broad spectrum of proteases, including trypsin, thrombin and collagenase. It can also inhibit inflammatory cytokines, and it thus disrupts inflammatory cascades. Mutations in this gene are a cause of alpha-2-macroglobulin deficiency. This gene is implicated in Alzheimers disease (AD) due to its ability to mediate the clearance and degradation of A-beta, the major component of beta-amyloid deposits. A related pseudogene, which is also located on the p arm of chromosome 12, has been identified. [provided by RefSeq, Nov 2016]
Reactivity
Human, Mouse, Rat
Storage Instruction
-20°C or -80°C,2°C to 8°C
UNSPSC
12352203

Combined proteomic and metabolomic analyses of cerebrospinal fluid from mice with ischemic stroke reveals the effects of a Buyang Huanwu decoction in neurodegenerative disease. Hsu WH et al., 2019, PLoS One
Read more