Bio-Connect

alpha Smooth Muscle Actin antibody [1A4] (ready-to-use)

GTX73419
GeneTex
ApplicationsFlow Cytometry, ImmunoHistoChemistry, ImmunoHistoChemistry Frozen, ImmunoHistoChemistry Paraffin
Product group Antibodies
ReactivityHuman, Mouse, Rat
TargetACTA2
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Overview

  • Supplier
    GeneTex
  • Product Name
    alpha Smooth Muscle Actin antibody [1A4] (ready-to-use)
  • Delivery Days Customer
    9
  • Antibody Specificity
    This antibody is specific to α-smooth muscle isoform of actin. It reacts with smooth muscle cells of vessels and different parenchymes. This antibody does not cross-react with β and γ-cytoplasmic, α-sarcomeric and α-myocardial act
  • Application Supplier Note
    *Optimal dilutions/concentrations should be determined by the researcher.Not tested in other applications.
  • Applications
    Flow Cytometry, ImmunoHistoChemistry, ImmunoHistoChemistry Frozen, ImmunoHistoChemistry Paraffin
  • Certification
    Research Use Only
  • Clonality
    Monoclonal
  • Clone ID
    1A4
  • Conjugate
    Unconjugated
  • Gene ID59
  • Target name
    ACTA2
  • Target description
    actin alpha 2, smooth muscle
  • Target synonyms
    actin, alpha 2, smooth muscle, aorta; actin, aortic smooth muscle; ACTSA; alpha-cardiac actin; cell growth-inhibiting gene 46 protein
  • Host
    Mouse
  • Isotype
    IgG2a
  • Protein IDP62736
  • Protein Name
    Actin, aortic smooth muscle
  • Scientific Description
    This gene encodes one of six different actin proteins. Actins are highly conserved proteins that are involved in cell motility, structure, integrity, and intercellular signaling. The encoded protein is a smooth muscle actin that is involved in vascular contractility and blood pressure homeostasis. Mutations in this gene cause a variety of vascular diseases, such as thoracic aortic disease, coronary artery disease, stroke, and Moyamoya disease, as well as multisystemic smooth muscle dysfunction syndrome. [provided by RefSeq, Sep 2017]
  • Reactivity
    Human, Mouse, Rat
  • Storage Instruction
    2°C to 8°C
  • UNSPSC
    12352203

References

  • Nimodipine augments cerebrovascular reactivity in aging but runs the risk of local perfusion reduction in acute cerebral ischemia.
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  • Fibroblast-specific Stat1 deletion enhances the myofibroblast phenotype during tissue repair. Medley SC et al., 2020 Jul, Wound Repair Regen
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  • The antagonism of prostaglandin FP receptors inhibits the evolution of spreading depolarization in an experimental model of global forebrain ischemia. Varga DP et al., 2020 Apr, Neurobiol Dis
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  • Cholinergic anti-inflammatory pathway inhibits neointimal hyperplasia by suppressing inflammation and oxidative stress. Li DJ et al., 2018 May, Redox Biol
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  • Targeting high mobility group box protein 1 ameliorates testicular inflammation in experimental autoimmune orchitis. Aslani F et al., 2015 Feb, Hum Reprod
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  • Effect of induced myopia on scleral myofibroblasts and in vivo ocular biomechanical compliance in the guinea pig. Backhouse S et al., 2010 Dec, Invest Ophthalmol Vis Sci
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  • Significance of PGP9.5 expression in cancer-associated fibroblasts for prognosis of colorectal carcinoma. Akishima-Fukasawa Y et al., 2010 Jul, Am J Clin Pathol
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