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alpha Smooth Muscle Actin antibody [1A4] (FITC)

GTX72531
GeneTex
ApplicationsFlow Cytometry, ImmunoFluorescence, ImmunoCytoChemistry, ImmunoHistoChemistry, ImmunoHistoChemistry Frozen, ImmunoHistoChemistry Paraffin
Product group Antibodies
TargetACTA2
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Overview

  • Supplier
    GeneTex
  • Product Name
    alpha Smooth Muscle Actin antibody [1A4] (FITC)
  • Delivery Days Customer
    9
  • Application Supplier Note
    For IF: Use at 10-20 microg/ml for 2 hours at room temperature. For IF: paraffin-embedded or frozen sections, as well as on cell smears can be used. Optimal dilutions/concentrations should be determined by the end user.
  • Applications
    Flow Cytometry, ImmunoFluorescence, ImmunoCytoChemistry, ImmunoHistoChemistry, ImmunoHistoChemistry Frozen, ImmunoHistoChemistry Paraffin
  • Certification
    Research Use Only
  • Clonality
    Monoclonal
  • Clone ID
    1A4
  • Conjugate
    FITC
  • Gene ID59
  • Target name
    ACTA2
  • Target description
    actin alpha 2, smooth muscle
  • Target synonyms
    actin, alpha 2, smooth muscle, aorta; actin, aortic smooth muscle; ACTSA; alpha-cardiac actin; cell growth-inhibiting gene 46 protein
  • Host
    Mouse
  • Isotype
    IgG2a
  • Protein IDP62736
  • Protein Name
    Actin, aortic smooth muscle
  • Scientific Description
    This gene encodes one of six different actin proteins. Actins are highly conserved proteins that are involved in cell motility, structure, integrity, and intercellular signaling. The encoded protein is a smooth muscle actin that is involved in vascular contractility and blood pressure homeostasis. Mutations in this gene cause a variety of vascular diseases, such as thoracic aortic disease, coronary artery disease, stroke, and Moyamoya disease, as well as multisystemic smooth muscle dysfunction syndrome. [provided by RefSeq, Sep 2017]
  • Storage Instruction
    2°C to 8°C
  • UNSPSC
    12352203

References

  • Extracellular Vesicles From Mesenchymal Umbilical Cord Cells Exert Protection Against Oxidative Stress and Fibrosis in a Rat Model of Bronchopulmonary Dysplasia.
    Read more
  • A T Cell-Engaging Tumor Organoid Platform for Pancreatic Cancer Immunotherapy.
    Read more
  • Nimodipine augments cerebrovascular reactivity in aging but runs the risk of local perfusion reduction in acute cerebral ischemia.
    Read more
  • Fibroblast-specific Stat1 deletion enhances the myofibroblast phenotype during tissue repair. Medley SC et al., 2020 Jul, Wound Repair Regen
    Read more
  • The antagonism of prostaglandin FP receptors inhibits the evolution of spreading depolarization in an experimental model of global forebrain ischemia. Varga DP et al., 2020 Apr, Neurobiol Dis
    Read more
  • Cancer-associated fibroblasts from lung tumors maintain their immunosuppressive abilities after high-dose irradiation. Gorchs L et al., 2015, Front Oncol
    Read more
  • Atypical chemokine receptor 1 deficiency reduces atherogenesis in ApoE-knockout mice. Wan W et al., 2015 Jun 1, Cardiovasc Res
    Read more
  • Targeting high mobility group box protein 1 ameliorates testicular inflammation in experimental autoimmune orchitis. Aslani F et al., 2015 Feb, Hum Reprod
    Read more
  • Effect of induced myopia on scleral myofibroblasts and in vivo ocular biomechanical compliance in the guinea pig. Backhouse S et al., 2010 Dec, Invest Ophthalmol Vis Sci
    Read more
  • Significance of PGP9.5 expression in cancer-associated fibroblasts for prognosis of colorectal carcinoma. Akishima-Fukasawa Y et al., 2010 Jul, Am J Clin Pathol
    Read more

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