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alpha Smooth Muscle Actin antibody [1A4] (FITC)

GTX72531
GeneTex
ApplicationsFlow Cytometry, ImmunoFluorescence, ImmunoCytoChemistry, ImmunoHistoChemistry, ImmunoHistoChemistry Frozen, ImmunoHistoChemistry Paraffin
Product group Antibodies
TargetACTA2
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Overview

  • Supplier
    GeneTex
  • Product Name
    alpha Smooth Muscle Actin antibody [1A4] (FITC)
  • Delivery Days Customer
    9
  • Application Supplier Note
    For IF: Use at 10-20 microg/ml for 2 hours at room temperature. For IF: paraffin-embedded or frozen sections, as well as on cell smears can be used. Optimal dilutions/concentrations should be determined by the end user.
  • Applications
    Flow Cytometry, ImmunoFluorescence, ImmunoCytoChemistry, ImmunoHistoChemistry, ImmunoHistoChemistry Frozen, ImmunoHistoChemistry Paraffin
  • Certification
    Research Use Only
  • Clonality
    Monoclonal
  • Clone ID
    1A4
  • Conjugate
    FITC
  • Gene ID59
  • Target name
    ACTA2
  • Target description
    actin alpha 2, smooth muscle
  • Target synonyms
    ACTSA, SMDYS, actin, aortic smooth muscle, actin, alpha 2, smooth muscle, aorta, alpha-cardiac actin, cell growth-inhibiting gene 46 protein
  • Host
    Mouse
  • Isotype
    IgG2a
  • Protein IDP62736
  • Protein Name
    Actin, aortic smooth muscle
  • Scientific Description
    This gene encodes one of six different actin proteins. Actins are highly conserved proteins that are involved in cell motility, structure, integrity, and intercellular signaling. The encoded protein is a smooth muscle actin that is involved in vascular contractility and blood pressure homeostasis. Mutations in this gene cause a variety of vascular diseases, such as thoracic aortic disease, coronary artery disease, stroke, and Moyamoya disease, as well as multisystemic smooth muscle dysfunction syndrome. [provided by RefSeq, Sep 2017]
  • Storage Instruction
    2°C to 8°C
  • UNSPSC
    12352203

References

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  • Kecskés S, Menyhárt Á, Bari F, et al. Nimodipine augments cerebrovascular reactivity in aging but runs the risk of local perfusion reduction in acute cerebral ischemia. Front Aging Neurosci. 2023,15:1175281. doi: 10.3389/fnagi.2023.1175281
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  • Gorchs L, Hellevik T, Bruun JA, et al. Cancer-associated fibroblasts from lung tumors maintain their immunosuppressive abilities after high-dose irradiation. Front Oncol. 2015,5:87. doi: 10.3389/fonc.2015.00087
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  • Backhouse S, Phillips JR. Effect of induced myopia on scleral myofibroblasts and in vivo ocular biomechanical compliance in the guinea pig. Invest Ophthalmol Vis Sci. 2010,51(12):6162-71. doi: 10.1167/iovs.10-5387
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  • Akishima-Fukasawa Y, Ino Y, Nakanishi Y, et al. Significance of PGP9.5 expression in cancer-associated fibroblasts for prognosis of colorectal carcinoma. Am J Clin Pathol. 2010,134(1):71-9. doi: 10.1309/AJCPRJP39MIDSGBH
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