Als2Cr2 Antibody / STRADB

Biorbyt

Als2Cr2 Antibody / STRADB

16

Provided assay concentrations are suggestions only, Als2Cr2 antibody titration may be required for optimal results. This antibody will detect the 418 (ILPIP alpha) and 280 (ILPIP beta) amino acid isoforms.

Western Blot

Western blot: 5-10ug/ml WB

Research Use Only

Polyclonal

Unconjugated

STRADB

STE20 related adaptor beta

ALS2CR2; amyotrophic lateral sclerosis 2 (juvenile) chromosome region, candidate 2; amyotrophic lateral sclerosis 2 chromosomal region candidate gene 2 protein; CALS-21; ILP-interacting protein ILPIPA; ILPIP; ILPIPA; PAPK; PRO1038; pseudokinase ALS2CR2; STE20-related kinase adapter protein beta; STE20-related kinase adaptor beta; STRAD beta

Rabbit

IgG

Als2Cr2, also called STE20-related kinase adapter protein beta (STRAD beta) and ILPIP, is a serine/threonine protein kinase encoded by the STRADB gene, discovered as an XIAP interacting protein. It is a mediator of the XIAP/TAK1 activation of the JNK1 pathway, an apoptosis inhibition mechanism independent of XIAP inhibition of caspases. Alone, it only moderately activates JNKs, but its interaction with XIAP/TAK1 induces a much stronger activation of JNK1, protecting against Caspase 1- or Fas-induced apoptosis.

Human, Mouse, Rat

-20°C

12352203