AMG-548 [864249-60-5]

MedChem Express

AMG-548 [864249-60-5]

10

864249-60-5

Research Use Only

99.0

C29H27N5O

461.56

AMG-548, an orally active and selective p38alpha inhibitor (Ki=0.5 nM), shows slightly selective over p38beta (Ki=36 nM) and >1000 fold selective against p38gamma and p38delta. AMG 548 is also extremely potent in the inhibition of whole blood LPS stimulated TNFalpha (IC50=3 nM)[1]. AMG-548 inhibits Wnt signaling by directly inhibiting Casein kinase 1 isoforms delta and epsilon[2].

O=C1N(C)C(NC[C@@H](N)CC2=CC=CC=C2)=NC(C3=CC=NC=C3)=C1C4=CC=C5C=CC=CC5=C4

-20°C

12352200