AMG-548

Biorbyt

AMG-548

10

864249-60-5

Research Use Only

C29H27N5O

461.569

AMG-548 is a potent and selective inhibitor of p38alpha with Ki of 0.5 nM, dispalys weak inhibition for p38beta (Ki=3.6 nM), and > 5,000-fold selectivity over p38gamma and p38delta; shows > 1,000-fold selectivity over other 36 kinases, and is efficacious in acute and chro

C1=CC=C(C[C@@H](CNC2=NC(C3=CC=NC=C3)=C(C3C=CC4=CC=CC=C4C=3)C(=O)N2C)N)C=C1

12352200