AMG-548 [864249-60-5]

TargetMol Chemicals

AMG-548 [864249-60-5]

44

864249-60-5

Chemical

Research Use Only

AMG-548

C29H27N5O

461.56

AMG-548 is an orally active and selective p38alpha inhibitor (Ki=0.5 nM), shows slightly selective over p38beta (Ki=36 nM) and >1000 fold selective against p38gamma and p38delta and is also extremely potent in the inhibition of whole blood LPS stimulated TNFalpha (IC50=3 nM)[1]. AMG-548 inhibits Wnt signaling by directly inhibiting Casein kinase 1 isoforms delta and epsilon[2].

3 years

O=C1C(=C(N=C(NC[C@H](CC2=CC=CC=C2)N)N1C)C=3C=CN=CC3)C4=CC5=C(C=C4)C=CC=C5

-20°C

12352200