Western Blot analysis of K562 cells using AMPK alpha1/2 Polyclonal Antibody at dilution of 1:500.
Western Blot analysis of K562 cells using AMPK alpha1/2 Polyclonal Antibody at dilution of 1:500.
AMPKalpha1/2 Polyclonal Antibody
E-AB-30491
Product group Antibodies
Overview
- SupplierElabscience
- Product NameAMPKalpha1/2 Polyclonal Antibody
- Delivery Days Customer12
- Applications SupplierWB,IHC,ELISA
- CertificationResearch Use Only
- Concentration1 mg/ml
- Scientific DescriptionAMPK (for 5-AMP-activated protein kinase) is a heterotrimeric complex comprising a catalytic alpha subunit and regulatory beta and gamma subunits. It protects cells from stresses that cause ATP depletion by switching off ATP-consuming biosynthetic pathways. AMPK is activated by high AMP and low ATP through a mechanism involving allosteric regulation, promotion of phosphorylation by an upstream protein kinase known as AMPK kinase, and inhibition of dephosphorylation.Activated AMPK can phosphorylate and regulate in vivo hydroxymethylglutaryl-CoA reductase and acetyl-CoA carboxylase, which are key regulatory enzymes of sterol synthesis and fatty acid synthesis, respectively.
- UNSPSC12352203