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ProductsBack/Angiopoietin 2 antibody [Angy-2-1]
Binding of human Angiopoietin-2 to Tie-2 (human):Fc is inhibited by the antibody anti-Angiopoietin-2, mAb (rec.) (blocking) (Angy-2-1). Methods: Tie-2 (h):Fc was coated on an ELISA plate at 1microg/ml. anti-Angiopoietin-2, mAb (rec.) (blocking) (Angy-2-1) or an unrelated mAb (recombinant) (Control) were added (starting at 40microg/ml with a twofold serial dilution) together with 20ng/microl of Angiopoietin-2 (human). After incubation for 1h at RT, the binding was detected using an anti-FLAG antibody (HRP).
Binding of human Angiopoietin-2 to Tie-2 (human):Fc is inhibited by the antibody anti-Angiopoietin-2, mAb (rec.) (blocking) (Angy-2-1). Methods: Tie-2 (h):Fc was coated on an ELISA plate at 1microg/ml. anti-Angiopoietin-2, mAb (rec.) (blocking) (Angy-2-1) or an unrelated mAb (recombinant) (Control) were added (starting at 40microg/ml with a twofold serial dilution) together with 20ng/microl of Angiopoietin-2 (human). After incubation for 1h at RT, the binding was detected using an anti-FLAG antibody (HRP).
Binding of human Angiopoietin-2 to Tie-2 (human):Fc is inhibited by the antibody anti-Angiopoietin-2, mAb (rec.) (blocking) (Angy-2-1). Methods: Tie-2 (h):Fc was coated on an ELISA plate at 1microg/ml. anti-Angiopoietin-2, mAb (rec.) (blocking) (Angy-2-1) or an unrelated mAb (recombinant) (Control) were added (starting at 40microg/ml with a twofold serial dilution) together with 20ng/microl of Angiopoietin-2 (human). After incubation for 1h at RT, the binding was detected using an anti-FLAG antibody (HRP).

Angiopoietin 2 antibody [Angy-2-1]

GTX33916
GeneTex
ApplicationsELISA, Neutralisation/Blocking
Product group Antibodies
ReactivityHuman, Mouse
TargetANGPT2
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Overview

  • Supplier
    GeneTex
  • Product Name
    Angiopoietin 2 antibody [Angy-2-1]
  • Delivery Days Customer
    9
  • Application Supplier Note
    Neutralizing/Inhibition: . *Optimal dilutions/concentrations should be determined by the researcher.Not tested in other applications.
  • Applications
    ELISA, Neutralisation/Blocking
  • Certification
    Research Use Only
  • Clonality
    Monoclonal
  • Clone ID
    Angy-2-1
  • Concentration
    1 mg/ml
  • Conjugate
    Unconjugated
  • Gene ID285
  • Target name
    ANGPT2
  • Target description
    angiopoietin 2
  • Target synonyms
    AGPT2, ANG2, LMPHM10, angiopoietin-2, Tie2-ligand, angiopoietin-2B, angiopoietin-2a
  • Host
    Mouse
  • Isotype
    IgG2b
  • Protein IDO15123
  • Protein Name
    Angiopoietin-2
  • Scientific Description
    The protein encoded by this gene is an antagonist of angiopoietin 1 (ANGPT1) and endothelial TEK tyrosine kinase (TIE-2, TEK). The encoded protein disrupts the vascular remodeling ability of ANGPT1 and may induce endothelial cell apoptosis. Three transcript variants encoding three different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
  • Reactivity
    Human, Mouse
  • Storage Instruction
    -20°C or -80°C,2°C to 8°C
  • UNSPSC
    12352203

References

  • Zhong J, Lu W, Zhang J, et al. Notoginsenoside R1 activates the Ang2/Tie2 pathway to promote angiogenesis. Phytomedicine. 2020,78:153302. doi: 10.1016/j.phymed.2020.153302
    Read this paper
  • An YA, Sun K, Joffin N, et al. Angiopoietin-2 in white adipose tissue improves metabolic homeostasis through enhanced angiogenesis. Elife. 2017,6:pii: e24071. doi: 10.7554/eLife.24071.
    Read this paper
  • Yun JH, Park SW, Kim JH, et al. Angiopoietin 2 induces astrocyte apoptosis via αvβ5-integrin signaling in diabetic retinopathy. Cell Death Dis. 2016,7(2):e2101. doi: 10.1038/cddis.2015.347
    Read this paper

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