Anti-ACE2 [h166D4 ]

Absolute Antibody

Anti-ACE2 [h166D4 ]

9

This antibody binds the extracellular domain of the human ACE2 protein. Angiotensin-converting enzyme 2 (ACE2) is a carboxypeptidase enzyme which catalyzes the cleavage of angiotensin I to angiotensin 1-9 and angiotensin II into the vasodilator angiotensi

The binding characterization of this antibody was done using ELISA. The antibody was reported to bind human ACE2 with a binding affinity of 6.57x10^(-9) M. This antibody can completely block the binding of SARS-CoV-2 RBD to hACE2 and thereby inhibit the infection in host. This antibody can also inhibit the infection of Vero E6 cells with SARS-CoV-2 live virus with high activity, and its IC 50 was 0.22 microg/mL (CN113698487).

ELISA, Neutralisation/Blocking

Research Use Only

Monoclonal

h166D4

ACE2

angiotensin converting enzyme 2

ACEH; ACE-related carboxypeptidase; angiotensin I converting enzyme (peptidyl-dipeptidase A) 2; angiotensin I converting enzyme 2; angiotensin-converting enzyme 2; angiotensin-converting enzyme homolog; angiotensin-converting enzyme-related carboxypeptidase; metalloprotease MPROT15; peptidyl-dipeptidase A; truncated angiotensin converting enzyme 2

Human

IgG4

Angiotensin-converting enzyme 2

Human

-20°C,2°C to 8°C

12352203