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Anti-alpha 5 beta 1 Integrin [M200 (Volociximab)]

Ab00449-1.1
Absolute Antibody
ApplicationsFlow Cytometry, ImmunoFluorescence, ELISA, ImmunoHistoChemistry, Neutralisation/Blocking
Product group Antibodies
TargetITGA5
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Overview

  • Supplier
    Absolute Antibody
  • Product Name
    Anti-alpha 5 beta 1 Integrin [M200 (Volociximab)]
  • Delivery Days Customer
    7
  • Application Supplier Note
    The antibody binds specifically to alpha5beta1 integrin, which is part of the superfamily of glycoprotein transmembrane receptors for ligands such as fibronectin, vitronectin, laminins and collagens. The alpha5beta1 integrin receptor plays a key role in cellular processes such as inflammation, cell proliferation, angiogenesis and tumour metastasis. Comprising the variable domain of the original mouse antibody, a chimeric mouse:human IgG4 version of this antibody has been tested in vivo: In cynomolgus monkeys with laser-induced choroidal neovascularization (CNV), in rabbit models and in human volunteers. The antibody reached Phase II clinical trials with PDL Biopharma and Biogen-Idec.
  • Applications
    Flow Cytometry, ImmunoFluorescence, ELISA, ImmunoHistoChemistry, Neutralisation/Blocking
  • Applications Supplier
    ELISA; FC; IF; Block; IHC
  • Certification
    Research Use Only
  • Clonality
    Monoclonal
  • Clone ID
    M200 (Volociximab)
  • Gene ID3678
  • Target name
    ITGA5
  • Target description
    integrin subunit alpha 5
  • Target synonyms
    CD49 antigen-like family member E; CD49e; fibronectin receptor subunit alpha; fibronectin receptor, alpha polypeptide; fibronectin receptor, alpha subunit; FNRA; integrin alpha-5; integrin alpha-F; integrin, alpha 5 (fibronectin receptor, alpha polypeptide); ITGA5/SLC9B1 fusion; very late activation protein 5, alpha subunit; VLA-5; VLA5A
  • Host
    Mouse
  • Isotype
    IgG1
  • Protein IDP08648
  • Protein Name
    Integrin alpha-5
  • Scientific Description
    NOT FOR THERAPEUTIC USE - This is a research-grade biosimilar. This chimeric mouse antibody was made using the variable domain sequences of the original Human IgG4 format, for improved compatibility with existing reagents, assays and techniques.
  • Reactivity Supplier
    Human
  • Reactivity Supplier Note
    Heterodimeric alfa5bèta1Fc fusion protein
  • Storage Instruction
    -20°C,2°C to 8°C
  • UNSPSC
    12352203

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