anti-ANO1 [TMEM16A] (human), Rabbit Monoclonal (RM440)

RevMAb Biosciences

anti-ANO1 [TMEM16A] (human), Rabbit Monoclonal (RM440)

10

ImmunoHistoChemistry

Research Use Only

Monoclonal

RM440

ANO1

anoctamin 1

anoctamin 1, calcium activated chloride channel; anoctamin-1; Ca2+-activated Cl- channel; calcium activated chloride channel; discovered on gastrointestinal stromal tumors protein 1; DOG1; oral cancer overexpressed 2; ORAOV2; TAOS2; TMEM16A; transmembrane protein 16A (eight membrane-spanning domains); tumor-amplified and overexpressed sequence 2

Rabbit

IgG

Anoctamin-1

ANO1 is a calcium-activated chloride channel (CaCC) which plays a role in transepithelial anion transport and smooth muscle contraction. It is required for the normal functioning of the interstitial cells of Cajal (ICCs) which generate electrical pacemaker activity in gastrointestinal smooth muscles. ANO1 acts as a major contributor to basal and stimulated chloride conductance in airway epithelial cells and plays an important role in tracheal cartilage development. Its overexpression was reported in esophageal squamous cell carcinoma and breast cancer progression. - Recombinant Antibody. This antibody reacts to human ANO1. Apllication: IHC. Liquid. 50% Glycerol/PBS with 1% BSA and 0.09% sodium azide. ANO1 is a calcium-activated chloride channel (CaCC) which plays a role in transepithelial anion transport and smooth muscle contraction. It is required for the normal functioning of the interstitial cells of Cajal (ICCs) which generate electrical pacemaker activity in gastrointestinal smooth muscles. ANO1 acts as a major contributor to basal and stimulated chloride conductance in airway epithelial cells and plays an important role in tracheal cartilage development. Its overexpression was reported in esophageal squamous cell carcinoma and breast cancer progression.

-20°C

12352203