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anti-ANO1 [TMEM16A] (human), Rabbit Monoclonal (RM440)

Research Use Only
REV-31-1331-00
RevMAb Biosciences
ApplicationsImmunoHistoChemistry
Product group Antibodies
ReactivityHuman
TargetANO1
Price on request
Packing Size
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Overview

  • Supplier
    RevMAb Biosciences
  • Product Name
    anti-ANO1 [TMEM16A] (human), Rabbit Monoclonal (RM440)
  • Delivery Days Customer
    5
  • Applications
    ImmunoHistoChemistry
  • Certification
    Research Use Only
  • Clonality
    Monoclonal
  • Clone ID
    RM440
  • Gene ID55107
  • Target name
    ANO1
  • Target description
    anoctamin 1
  • Target synonyms
    anoctamin 1, calcium activated chloride channel; anoctamin-1; Ca2+-activated Cl- channel; calcium activated chloride channel; discovered on gastrointestinal stromal tumors protein 1; DOG1; oral cancer overexpressed 2; ORAOV2; TAOS2; TMEM16A; transmembrane protein 16A (eight membrane-spanning domains); tumor-amplified and overexpressed sequence 2
  • Host
    Rabbit
  • Isotype
    IgG
  • Scientific Description
    ANO1 is a calcium-activated chloride channel (CaCC) which plays a role in transepithelial anion transport and smooth muscle contraction. It is required for the normal functioning of the interstitial cells of Cajal (ICCs) which generate electrical pacemaker activity in gastrointestinal smooth muscles. ANO1 acts as a major contributor to basal and stimulated chloride conductance in airway epithelial cells and plays an important role in tracheal cartilage development. Its overexpression was reported in esophageal squamous cell carcinoma and breast cancer progression. - Recombinant Antibody. This antibody reacts to human ANO1. Apllication: IHC. Liquid. 50% Glycerol/PBS with 1% BSA and 0.09% sodium azide. ANO1 is a calcium-activated chloride channel (CaCC) which plays a role in transepithelial anion transport and smooth muscle contraction. It is required for the normal functioning of the interstitial cells of Cajal (ICCs) which generate electrical pacemaker activity in gastrointestinal smooth muscles. ANO1 acts as a major contributor to basal and stimulated chloride conductance in airway epithelial cells and plays an important role in tracheal cartilage development. Its overexpression was reported in esophageal squamous cell carcinoma and breast cancer progression.
  • Reactivity
    Human
  • Storage Instruction
    -20°C
  • UNSPSC
    12352203