Anti-APC Antibody

HUABIO

Anti-APC Antibody

7

Flow Cytometry, ImmunoFluorescence, Western Blot, ImmunoHistoChemistry, ImmunoHistoChemistry Frozen, ImmunoHistoChemistry Paraffin

WB,IF-Cell,IHC-P,FC

Research Use Only

Polyclonal

1 mg/ml

Unconjugated

APC

APC regulator of Wnt signaling pathway

BTPS2, DESMD, DP2, DP2.5, DP3, GS, PPP1R46, adenomatous polyposis coli protein, APC, WNT signaling pathway regulator, WNT signaling pathway regulator, adenomatosis polyposis coli tumor suppressor, adenomatous polyposis coli (APC), deleted in polyposis 2.5, epididymis secretory sperm binding protein, protein phosphatase 1, regulatory subunit 46

Rabbit

IgG

Adenomatous polyposis coli protein

The adenomatous polyposis syndromes, familial adenomatous polyposis (FAP) and Gardners syndrome (GS), are characterized by numerous adenomatous polyps throughout the entire colon. These polyps invariably progress to colon cancer in addition to other extracolonic manifestations. The cloning of the APC gene revealed a ubiquitously expressed protein, 2,843 amino acids in length, which is frequently mutated in patients suffering from FAP and GS. APC has been found to be associated with structural components of intracellular junctions. beta-catenin and gamma-catenin (also called plakoglobin), are involved in the regulation of cellular adhesion. APC and E-cadherin compete for binding to specific internal regions of both beta- and gamma-catenin. Interactions between cytoskeleton and the APC, E-cadherin, beta/gamma catenin complex are mediated by alpha-catenin.

Human, Mouse, Rat

Human,Mouse,Rat

-20°C,2°C to 8°C

41116161