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APC antibody [C3], C-term

GTX116009
GeneTex
ApplicationsImmunoFluorescence, Western Blot, ImmunoCytoChemistry, ImmunoHistoChemistry, ImmunoHistoChemistry Paraffin
Product group Antibodies
TargetAPC
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Overview

  • Supplier
    GeneTex
  • Product Name
    APC antibody [C3], C-term
  • Delivery Days Customer
    9
  • Application Supplier Note
    WB: 1:500-1:3000. ICC/IF: 1:100-1:1000. IHC-P: 1:100-1:1000. *Optimal dilutions/concentrations should be determined by the researcher.Not tested in other applications.
  • Applications
    ImmunoFluorescence, Western Blot, ImmunoCytoChemistry, ImmunoHistoChemistry, ImmunoHistoChemistry Paraffin
  • Certification
    Research Use Only
  • Clonality
    Polyclonal
  • Concentration
    1.44 mg/ml
  • Conjugate
    Unconjugated
  • Gene ID324
  • Target name
    APC
  • Target description
    APC regulator of Wnt signaling pathway
  • Target synonyms
    BTPS2, DESMD, DP2, DP2.5, DP3, GS, PPP1R46, adenomatous polyposis coli protein, APC, WNT signaling pathway regulator, WNT signaling pathway regulator, adenomatosis polyposis coli tumor suppressor, adenomatous polyposis coli (APC), deleted in polyposis 2.5, epididymis secretory sperm binding protein, protein phosphatase 1, regulatory subunit 46
  • Host
    Rabbit
  • Isotype
    IgG
  • Protein IDP25054
  • Protein Name
    Adenomatous polyposis coli protein
  • Scientific Description
    This gene encodes a tumor suppressor protein that acts as an antagonist of the Wnt signaling pathway. It is also involved in other processes including cell migration and adhesion, transcriptional activation, and apoptosis. Defects in this gene cause familial adenomatous polyposis (FAP), an autosomal dominant pre-malignant disease that usually progresses to malignancy. Disease-associated mutations tend to be clustered in a small region designated the mutation cluster region (MCR) and result in a truncated protein product. [provided by RefSeq]
  • Storage Instruction
    -20°C or -80°C,2°C to 8°C
  • UNSPSC
    12352203

References

  • Degl'Innocenti E, Poloni TE, Medici V, et al. Centrin 2: A Novel Marker of Mature and Neoplastic Human Astrocytes. Front Cell Neurosci. 2022,16:858347. doi: 10.3389/fncel.2022.858347
    Read this paper
  • Yamaguchi S, Fujii T, Izumi Y, et al. Identification and characterization of a novel adenomatous polyposis coli mutation in adult pancreatoblastoma. Oncotarget. 2018,9(12):10818-10827. doi: 10.18632/oncotarget.24017
    Read this paper
  • Moore S, Patel R, Hannsun G, et al. Sex chromosome complement influences functional callosal myelination. Neuroscience. 2013,245:166-78. doi: 10.1016/j.neuroscience.2013.04.017
    Read this paper