APC antibody [C3], C-term
GTX116009
ApplicationsImmunoFluorescence, Western Blot, ImmunoCytoChemistry, ImmunoHistoChemistry, ImmunoHistoChemistry Paraffin
Product group Antibodies
TargetAPC
Overview
- SupplierGeneTex
- Product NameAPC antibody [C3], C-term
- Delivery Days Customer9
- Application Supplier NoteWB: 1:500-1:3000. ICC/IF: 1:100-1:1000. IHC-P: 1:100-1:1000. *Optimal dilutions/concentrations should be determined by the researcher.Not tested in other applications.
- ApplicationsImmunoFluorescence, Western Blot, ImmunoCytoChemistry, ImmunoHistoChemistry, ImmunoHistoChemistry Paraffin
- CertificationResearch Use Only
- ClonalityPolyclonal
- Concentration1.44 mg/ml
- ConjugateUnconjugated
- Gene ID324
- Target nameAPC
- Target descriptionAPC regulator of Wnt signaling pathway
- Target synonymsBTPS2, DESMD, DP2, DP2.5, DP3, GS, PPP1R46, adenomatous polyposis coli protein, APC, WNT signaling pathway regulator, WNT signaling pathway regulator, adenomatosis polyposis coli tumor suppressor, adenomatous polyposis coli (APC), deleted in polyposis 2.5, epididymis secretory sperm binding protein, protein phosphatase 1, regulatory subunit 46
- HostRabbit
- IsotypeIgG
- Protein IDP25054
- Protein NameAdenomatous polyposis coli protein
- Scientific DescriptionThis gene encodes a tumor suppressor protein that acts as an antagonist of the Wnt signaling pathway. It is also involved in other processes including cell migration and adhesion, transcriptional activation, and apoptosis. Defects in this gene cause familial adenomatous polyposis (FAP), an autosomal dominant pre-malignant disease that usually progresses to malignancy. Disease-associated mutations tend to be clustered in a small region designated the mutation cluster region (MCR) and result in a truncated protein product. [provided by RefSeq]
- Storage Instruction-20°C or -80°C,2°C to 8°C
- UNSPSC12352203
References
- Degl'Innocenti E, Poloni TE, Medici V, et al. Centrin 2: A Novel Marker of Mature and Neoplastic Human Astrocytes. Front Cell Neurosci. 2022,16:858347. doi: 10.3389/fncel.2022.858347Read this paper
- Yamaguchi S, Fujii T, Izumi Y, et al. Identification and characterization of a novel adenomatous polyposis coli mutation in adult pancreatoblastoma. Oncotarget. 2018,9(12):10818-10827. doi: 10.18632/oncotarget.24017Read this paper
- Moore S, Patel R, Hannsun G, et al. Sex chromosome complement influences functional callosal myelination. Neuroscience. 2013,245:166-78. doi: 10.1016/j.neuroscience.2013.04.017Read this paper



