Immunohistochemical staining of formalin fixed and paraffin embedded human tonsil tissue sections using Anti-Aurora B Rabbit Monoclonal Antibody (Clone RM278) at a 1:500 dilution.
Immunohistochemical staining of formalin fixed and paraffin embedded human tonsil tissue sections using Anti-Aurora B Rabbit Monoclonal Antibody (Clone RM278) at a 1:500 dilution.
anti-Aurora-B (human), Rabbit Monoclonal (RM278)
REV-31-1159-00
ApplicationsWestern Blot, ImmunoHistoChemistry
Product group Antibodies
ReactivityHuman
TargetAURKB
Overview
- SupplierRevMAb Biosciences
- Product Nameanti-Aurora-B (human), Rabbit Monoclonal (RM278)
- Delivery Days Customer5
- ApplicationsWestern Blot, ImmunoHistoChemistry
- CertificationResearch Use Only
- ClonalityMonoclonal
- Clone IDRM278
- Gene ID9212
- Target nameAURKB
- Target descriptionaurora kinase B
- Target synonymsAIK2; AIM1; AIM-1; ARK2; ARK-2; AurB; aurkb-sv1; aurkb-sv2; aurora- and Ipl1-like midbody-associated protein 1; aurora kinase B; aurora kinase B-Sv1; aurora kinase B-Sv2; aurora/IPL1-related kinase 2; aurora-1; aurora-B; aurora-related kinase 2; IPL1; PPP1R48; protein phosphatase 1, regulatory subunit 48; serine/threonine kinase 12; serine/threonine-protein kinase 12; serine/threonine-protein kinase 5; serine/threonine-protein kinase aurora-B; STK-1; STK12; STK5
- HostRabbit
- IsotypeIgG
- Scientific DescriptionAurora-B plays a critical role in cell division and chromosome-microtubule interactions during mitosis. Aurora-B kinase is a serine/threonine kinase which is the enzymatic core of the Chromosomal Passenger Complex (CPC). This complex functions in chromosome alignment and separation, histone modification and cytokinesis. CPC also includes three non-enzymatic subunits known as the inner centromere protein (INCENP), survivin and borealin, which determine the activity, localization, stability and possibly even the substrate specificity of Aurora-B. Two CPCs exist during mitosis: one containing all four members and another consisting of INCENP and Aurora-B. Quaternary CPC functions during chromosome alignment and cytokinesis, whereas the INCENP-Aurora-B complex may be responsible for modifying histone H3. Aurora B phosphorylates Histone H3 at residues Serine 53 and Serine 28 during prophase, leading to the dissociation of HP1 from chromatin and condensation of chromosome. Aurora-B was found to be overexpressed in several malignant cancers and is involved in promoting tumor development and progression. - Recombinant Antibody. This antibody reacts to human Aurora kinase B. Applications: WB, IHC. Source: Rabbit. Liquid. 50% Glycerol/PBS with 1% BSA and 0.09% sodium azide. Aurora-B plays a critical role in cell division and chromosome-microtubule interactions during mitosis. Aurora-B kinase is a serine/threonine kinase which is the enzymatic core of the Chromosomal Passenger Complex (CPC). This complex functions in chromosome alignment and separation, histone modification and cytokinesis. CPC also includes three non-enzymatic subunits known as the inner centromere protein (INCENP), survivin and borealin, which determine the activity, localization, stability and possibly even the substrate specificity of Aurora-B. Two CPCs exist during mitosis: one containing all four members and another consisting of INCENP and Aurora-B. Quaternary CPC functions during chromosome alignment and cytokinesis, whereas the INCENP-Aurora-B complex may be responsible for modifying histone H3. Aurora B phosphorylates Histone H3 at residues Serine 53 and Serine 28 during prophase, leading to the dissociation of HP1 from chromatin and condensation of chromosome. Aurora-B was found to be overexpressed in several malignant cancers and is involved in promoting tumor development and progression.
- ReactivityHuman
- Storage Instruction-20°C
- UNSPSC12352203