anti-Aurora-B (human), Rabbit Monoclonal (RM278)

RevMAb Biosciences

anti-Aurora-B (human), Rabbit Monoclonal (RM278)

10

Western Blot, ImmunoHistoChemistry

Research Use Only

Monoclonal

RM278

AURKB

aurora kinase B

AIK2, AIM-1, AIM1, ARK-2, ARK2, AurB, IPL1, PPP1R48, STK-1, STK12, STK5, aurkb-sv1, aurkb-sv2, aurora kinase B, aurora kinase B-Sv1, aurora kinase B-Sv2, aurora- and Ipl1-like midbody-associated protein 1, aurora- and Ipl1-like midbody-associated protein 1 homolog, aurora-1, aurora-B, aurora-related kinase 2, aurora/IPL1-related kinase 2, protein phosphatase 1, regulatory subunit 48, serine/threonine kinase 12, serine/threonine-protein kinase 12, serine/threonine-protein kinase 5, serine/threonine-protein kinase aurora-B

Rabbit

IgG

Aurora kinase B

Aurora-B plays a critical role in cell division and chromosome-microtubule interactions during mitosis. Aurora-B kinase is a serine/threonine kinase which is the enzymatic core of the Chromosomal Passenger Complex (CPC). This complex functions in chromosome alignment and separation, histone modification and cytokinesis. CPC also includes three non-enzymatic subunits known as the inner centromere protein (INCENP), survivin and borealin, which determine the activity, localization, stability and possibly even the substrate specificity of Aurora-B. Two CPCs exist during mitosis: one containing all four members and another consisting of INCENP and Aurora-B. Quaternary CPC functions during chromosome alignment and cytokinesis, whereas the INCENP-Aurora-B complex may be responsible for modifying histone H3. Aurora B phosphorylates Histone H3 at residues Serine 53 and Serine 28 during prophase, leading to the dissociation of HP1 from chromatin and condensation of chromosome. Aurora-B was found to be overexpressed in several malignant cancers and is involved in promoting tumor development and progression. - Recombinant Antibody. This antibody reacts to human Aurora kinase B. Applications: WB, IHC. Source: Rabbit. Liquid. 50% Glycerol/PBS with 1% BSA and 0.09% sodium azide. Aurora-B plays a critical role in cell division and chromosome-microtubule interactions during mitosis. Aurora-B kinase is a serine/threonine kinase which is the enzymatic core of the Chromosomal Passenger Complex (CPC). This complex functions in chromosome alignment and separation, histone modification and cytokinesis. CPC also includes three non-enzymatic subunits known as the inner centromere protein (INCENP), survivin and borealin, which determine the activity, localization, stability and possibly even the substrate specificity of Aurora-B. Two CPCs exist during mitosis: one containing all four members and another consisting of INCENP and Aurora-B. Quaternary CPC functions during chromosome alignment and cytokinesis, whereas the INCENP-Aurora-B complex may be responsible for modifying histone H3. Aurora B phosphorylates Histone H3 at residues Serine 53 and Serine 28 during prophase, leading to the dissociation of HP1 from chromatin and condensation of chromosome. Aurora-B was found to be overexpressed in several malignant cancers and is involved in promoting tumor development and progression.

-20°C

12352203