Anti-B7-H4 [S2]

Absolute Antibody

Anti-B7-H4 [S2]

7

This antibody binds a linear epitope comprising amino acids (VIQWLKEGVLGLVHEFK) of the human B7-H4.

This antibody recognized intact wild type human B7-H4 and linear epitope comprising amino acids VIQWLKEGVLGLVHEFK in an ELISA. This antibody was also capable or recognizing B7-H4 in a western blot assay. The binding of this antibody to B7-H4 protein can effectively neutralize the immunosuppression response induced by B7-H4 proteins, thus enabling T-cells to retain their activation status (PMID: 33716253).

Western Blot, ELISA, Neutralisation/Blocking

ELISA; WB; Block

Research Use Only

Monoclonal

S2

VTCN1

V-set domain containing T cell activation inhibitor 1

B7 family member, H4; B7 homolog 4; B7 superfamily member 1; B7h.5; B7H4; B7-H4; B7S1; B7X; immune costimulatory protein B7-H4; PRO1291; T cell costimulatory molecule B7x; VCTN1; V-set domain-containing T-cell activation inhibitor 1

Human

IgG1

V-set domain-containing T-cell activation inhibitor 1

This full-length chimeric human antibody was made using the variable domain sequences of the original Chicken scFv format for improved compatibility with existing reagents assays and techniques.

Human

The original antibody was generated by immunizing female white leghorn chickens with 50 ug of recombinant B7-H4 protein (Phe29 to Ala258) through intramuscular injection. The spleens of the chickens were harvested 7 days after the final immunization to construct an scFv antibody library. The antibody was isolated by panning against B7-H4 protein.

-20°C,2°C to 8°C

12352203