Anti-BR3 [V3-46s]

Absolute Antibody

Anti-BR3 [V3-46s]

7

This antibody was used for ELISA on mBR3-ECD and hBR3-ECD (US20080181888). This antibody blocks BAFF-BR3 binding (US20080181888). The Fab version of this antibody bound mouse BR3-ECD and human BR3-ECD with an affinity of 1nM and 0.6nM respectively. Humanized V3-46s antibody also blocked BAFF binding to BR3 on BJAB cells and bound BR3 on BJAB cells. This antibody was used as a template to make homolog shotgun libraries (US20080181888).

ELISA, Neutralisation/Blocking

ELISA; Blocking

Research Use Only

Monoclonal

V3-46s

TNFRSF13C

TNF receptor superfamily member 13C

BAFF-R, BAFFR, BROMIX, CD268, CVID4, prolixin, tumor necrosis factor receptor superfamily member 13C, B cell-activating factor receptor, BAFF receptor, BLyS receptor 3

Human

IgG1

Tumor necrosis factor receptor superfamily member 13C

This reformatted human antibody was made using the variable domain sequences of the original Human Fab format, for improved compatibility with existing reagents, assays and techniques.

Human, mouse

The original antibody was generated from a synthetic antibody library that was built on a single human framework by introducing synthetic diversity at solvent-exposed positions within the heavy chain complementarity-determining regions.

-20°C,2°C to 8°C

12352203